Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus : Testing the “Two Hit” Hypothesis for the Development of Schizophrenia
المؤلفون المشاركون
Hodgson, Deborah M.
Zavitsanou, Katerina
Verdurand, Mathieu
Walker, Adam
Dalton, Victoria S.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Infections during pregnancy and adolescent cannabis use have both been identified as environmental risk factors for schizophrenia.
We combined these factors in an animal model and looked at their effects, alone and in combination, on serotonin 5HT1A receptor binding (5HT1AR) binding longitudinally from late adolescence to adulthood.
Pregnant rats were exposed to the viral mimic poly I:C on embryonic day 15.
Adolescent offspring received daily injections of the cannabinoid HU210 for 14 days starting on postnatal day (PND) 35.
Hippocampal and cortical 5HT1AR binding was quantified autoradiographically using [3H]8-OH-DPAT, in late adolescent (PND 55), young adult (PND 65) and adult (PND 90) rats.
Descendants of poly I:C treated rats showed significant increases of 15–18% in 5HT1AR in the hippocampus (CA1) compared to controls at all developmental ages.
Offspring of poly I:C treated rats exposed to HU210 during adolescence exhibited even greater elevations in 5HT1AR (with increases of 44, 29, and 39% at PNDs 55, 65, and 90).
No effect of HU210 alone was observed.
Our results suggest a synergistic effect of prenatal infection and adolescent cannabinoid exposure on the integrity of the serotoninergic system in the hippocampus that may provide the neurochemical substrate for abnormal hippocampal-related functions relevant to schizophrenia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dalton, Victoria S.& Verdurand, Mathieu& Walker, Adam& Hodgson, Deborah M.& Zavitsanou, Katerina. 2012. Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus : Testing the “Two Hit” Hypothesis for the Development of Schizophrenia. ISRN Psychiatry،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472662
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dalton, Victoria S.…[et al.]. Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus : Testing the “Two Hit” Hypothesis for the Development of Schizophrenia. ISRN Psychiatry No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-472662
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dalton, Victoria S.& Verdurand, Mathieu& Walker, Adam& Hodgson, Deborah M.& Zavitsanou, Katerina. Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus : Testing the “Two Hit” Hypothesis for the Development of Schizophrenia. ISRN Psychiatry. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472662
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472662
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر