Analysis of Therapeutic Effect of Ilex hainanensis Merr. Extract on Nonalcoholic Fatty Liver Disease through Urine Metabolite Profiling by Ultraperformance Liquid ChromatographyQuadrupole Time of Flight Mass Spectrometry
المؤلفون المشاركون
Chen, Gang-ling
Li, Jing-jing
Chen, Xiao-qing
Yang, Jie
Wen, Xiao-dong
Cui, Wei-xi
Wang, Qiang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, is increased worldwide in parallel with the obesity epidemic.
Our previous studies have showed that the extract of I.
hainanensis (EIH) can prevent NAFLD in rat fed with high-fat diet.
In this work, we aimed to find biomarkers of NAFLD and investigate the therapeutic effects of EIH.
NAFLD model was induced in male Sprague-Dawley rats by high-fat diet.
The NAFLD rats were administered EIH orally (250 mg/kg) for two weeks.
After the experimental period, samples of 24 h urine were collected and analyzed by ultraperformance liquid chromatography/quadrupole time of flight mass spectrometry (UPLC-Q-TOF).
Orthogonal partial least squares analysis (OPLSs) models were built to find biomarkers of NAFLD and investigate the therapeutic effects of EIH.
22 metabolites, which are distributed in several metabolic pathways, were identified as potential biomarkers of NAFLD.
Taking these biomarkers as screening indexes, EIH could reverse the pathological process of NAFLD through regulating the disturbed pathway of metabolism.
The metabolomic results not only supply a systematic view of the development and progression of NAFLD but also provide a theoretical basis for the prevention or treatment of NAFLD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jing-jing& Yang, Jie& Cui, Wei-xi& Chen, Xiao-qing& Chen, Gang-ling& Wen, Xiao-dong…[et al.]. 2013. Analysis of Therapeutic Effect of Ilex hainanensis Merr. Extract on Nonalcoholic Fatty Liver Disease through Urine Metabolite Profiling by Ultraperformance Liquid ChromatographyQuadrupole Time of Flight Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-472675
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jing-jing…[et al.]. Analysis of Therapeutic Effect of Ilex hainanensis Merr. Extract on Nonalcoholic Fatty Liver Disease through Urine Metabolite Profiling by Ultraperformance Liquid ChromatographyQuadrupole Time of Flight Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-472675
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jing-jing& Yang, Jie& Cui, Wei-xi& Chen, Xiao-qing& Chen, Gang-ling& Wen, Xiao-dong…[et al.]. Analysis of Therapeutic Effect of Ilex hainanensis Merr. Extract on Nonalcoholic Fatty Liver Disease through Urine Metabolite Profiling by Ultraperformance Liquid ChromatographyQuadrupole Time of Flight Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-472675
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472675
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر