Coexpression within Integrated Mitochondrial Pathways Reveals Different Networks in Normal and Chemically Treated Transcriptomes
المؤلفون المشاركون
Liu, Jiankang
Hyun, Tae Kyung
Li, Yuan
Feng, Zhihui
Chen, Cong
Han, Xiao
Liu, Xiaolong
المصدر
International Journal of Genomics
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
As energy producers, mitochondria play a pivotal role in multiple cellular processes.
Although several lines of evidence suggest that differential expression of mitochondrial respiratory complexes (MRCs) has a significant impact on mitochondrial function, the role of integrated MRCs in the whole coexpression network has yet to be revealed.
In this study, we construct coexpression networks based on microarray datasets from different tissues and chemical treatments to explore the role of integrated MRCs in the coexpression network and the effects of different chemicals on the mitochondrial network.
By grouping MRCs as one seed target, the hypergeometric distribution allowed us to identify genes that are significantly coexpress with whole MRCs.
Coexpression among 46 MRC genes (approximately 78% of MRC genes tested) was significant in the normal tissue transcriptome dataset.
These MRC genes are coexpressed with genes involved in the categories “muscle system process,” “metabolic process,” and “neurodegenerative disease pathways,” whereas, in the chemically treated tissues, coexpression of these genes mostly disappeared.
These results indicate that chemical stimuli alter the normal coexpression network of MRC genes.
Taken together, the datasets obtained from the different coexpression networks are informative about mitochondrial biogenesis and should contribute to understanding the side effects of drugs on mitochondrial function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Cong& Hyun, Tae Kyung& Han, Xiao& Feng, Zhihui& Li, Yuan& Liu, Xiaolong…[et al.]. 2014. Coexpression within Integrated Mitochondrial Pathways Reveals Different Networks in Normal and Chemically Treated Transcriptomes. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-472752
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Cong…[et al.]. Coexpression within Integrated Mitochondrial Pathways Reveals Different Networks in Normal and Chemically Treated Transcriptomes. International Journal of Genomics No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-472752
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Cong& Hyun, Tae Kyung& Han, Xiao& Feng, Zhihui& Li, Yuan& Liu, Xiaolong…[et al.]. Coexpression within Integrated Mitochondrial Pathways Reveals Different Networks in Normal and Chemically Treated Transcriptomes. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-472752
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472752
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر