The Pilot Study of Fibrin with Temporomandibular Joint Derived Synovial Stem Cells in Repairing TMJ Disc Perforation
المؤلفون المشاركون
Li, Jian
Fang, Wei
Meng, Qinggong
Wu, Yang
Gong, Zhongcheng
Long, Xing
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
TMJ disc related diseases are difficult to be cured due to the poor repair ability of the disc.
TMJ-SDSCs were ideal cell sources for cartilage tissue engineering which have been widely used in hyaline cartilage regeneration.
Fibrin gel has been demonstrated as a potential scaffold for neocartilage formation.
The aim of this study was to repair the TMJ disc perforation using fibrin/chitosan hybrid scaffold combined with TMJ-SDSCs.
Rat TMJ-SDSCs were cultured on hybrid scaffold or pure chitosan scaffolds.
The cell seeding efficiency, distribution, proliferation, and chondrogenic differentiation capacity were investigated.
To evaluate the in vivo repair ability of cell/scaffold construct, rat TMJ disc explants were punched with a defect to mimic TMJ disc perforation.
Cell seeded scaffolds were inserted into the defect of TMJ disc explants and then were implanted subcutaneously in nude mice for 4 weeks.
Results demonstrated that fibrin may improve cell seeding, proliferation, and chondrogenic induction in vitro.
The in vivo experiments showed more cartilage ECM deposition in fibrin/chitosan scaffold, which suggested an enhanced reparative ability.
This pilot study demonstrated that the regenerative ability of TMJ-SDSCs seeded in fibrin/chitosan scaffold could be applied for repairing TMJ disc perforation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Yang& Gong, Zhongcheng& Li, Jian& Meng, Qinggong& Fang, Wei& Long, Xing. 2014. The Pilot Study of Fibrin with Temporomandibular Joint Derived Synovial Stem Cells in Repairing TMJ Disc Perforation. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-472842
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Yang…[et al.]. The Pilot Study of Fibrin with Temporomandibular Joint Derived Synovial Stem Cells in Repairing TMJ Disc Perforation. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-472842
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Yang& Gong, Zhongcheng& Li, Jian& Meng, Qinggong& Fang, Wei& Long, Xing. The Pilot Study of Fibrin with Temporomandibular Joint Derived Synovial Stem Cells in Repairing TMJ Disc Perforation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-472842
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472842
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر