Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair : Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades
المؤلفون المشاركون
Wilkins-Port, Cynthia E.
Higgins, Craig E.
Higgins, Stephen P.
Higgins, Paul J.
Kobori-Hotchkiss, Issey
المصدر
Biochemistry Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Spatial and temporal regulation of the pericellular proteolytic environment by local growth factors, such as EGF and TGF-β, initiates a wide repertoire of cellular responses coupled to a plasmin/matrix metalloproteinase (MMP) dependent stromal-remodeling axis.
Cell motility and invasion, tumor metastasis, wound healing, and organ fibrosis, for example, represent diverse events controlled by expression of a subset of genes that encode various classes of tissue remodeling proteins.
These include members of the serine protease and MMP families that functionally constitute a complex system of interacting protease cascades and titrated by their respective inhibitors.
Several structural components of the extracellular matrix are upregulated by TGF-β as are matrix-active proteases (e.g., urokinase (uPA), plasmin, MMP-1, -3, -9, -10, -11, -13, -14).
Stringent controls on serine protease/MMP expression and their topographic activity are essential for maintaining tissue homeostasis.
Targeting individual elements in this highly interactive network may lead to novel therapeutic approaches for the treatment of cancer, fibrotic diseases, and chronic wounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wilkins-Port, Cynthia E.& Higgins, Stephen P.& Higgins, Craig E.& Kobori-Hotchkiss, Issey& Higgins, Paul J.. 2012. Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair : Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-472868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wilkins-Port, Cynthia E.…[et al.]. Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair : Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades. Biochemistry Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-472868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wilkins-Port, Cynthia E.& Higgins, Stephen P.& Higgins, Craig E.& Kobori-Hotchkiss, Issey& Higgins, Paul J.. Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair : Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-472868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر