Growth Inhibition of Re-Challenge B16 Melanoma Transplant by Conjugates of Melanogenesis Substrate and Magnetite Nanoparticles as the Basis for Developing Melanoma-Targeted Chemo-Thermo-Immunotherapy
المؤلفون المشاركون
Jimbow, Kowichi
Ito, Akira
Ono, Ichiro
Ito, Shosuke
Honda, Hiroyuki
Yamashita, Toshiharu
Sato, Makito
Sato, Akiko
Takada, Tomoaki
Miyamoto, Atsushi
Sato, Noriyuki
Wakamatsu, Kazumasa
Tamura, Yasuaki
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-10-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Melanogenesis substrate, N-propionyl-cysteaminylphenol (NPrCAP), is selectively incorporated into melanoma cells and inhibits their growth by producing cytotoxic free radicals.
Magnetite nanoparticles also disintegrate cancer cells and generate heat shock protein (HSP) upon exposure to an alternating magnetic field (AMF).
This study tested if a chemo-thermo-immunotherapy (CTI therapy) strategy can be developed for better management of melanoma by conjugating NPrCAP on the surface of magnetite nanoparticles (NPrCAP/M).
We examined the feasibility of this approach in B16 mouse melanoma and evaluated the impact of exposure temperature, frequency, and interval on the inhibition of re-challenged melanoma growth.
The therapeutic protocol against the primary transplanted tumor with or without AMF exposure once a day every other day for a total of three treatments not only inhibited the growth of the primary transplant but also prevented the growth of the secondary, re-challenge transplant.
The heat-generated therapeutic effect was more significant at a temperature of 43∘C than either 41∘C or 46∘C.
NPrCAP/M with AMF exposure, instead of control magnetite alone or without AMF exposure, resulted in the most significant growth inhibition of the re-challenge tumor and increased the life span of the mice.
HSP70 production was greatest at 43∘C compared to that with 41∘C or 46∘C.
CD+T cells were infiltrated at the site of the re-challenge melanoma transplant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takada, Tomoaki& Yamashita, Toshiharu& Sato, Makito& Sato, Akiko& Ono, Ichiro& Tamura, Yasuaki…[et al.]. 2009. Growth Inhibition of Re-Challenge B16 Melanoma Transplant by Conjugates of Melanogenesis Substrate and Magnetite Nanoparticles as the Basis for Developing Melanoma-Targeted Chemo-Thermo-Immunotherapy. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-473079
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takada, Tomoaki…[et al.]. Growth Inhibition of Re-Challenge B16 Melanoma Transplant by Conjugates of Melanogenesis Substrate and Magnetite Nanoparticles as the Basis for Developing Melanoma-Targeted Chemo-Thermo-Immunotherapy. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-13.
https://search.emarefa.net/detail/BIM-473079
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takada, Tomoaki& Yamashita, Toshiharu& Sato, Makito& Sato, Akiko& Ono, Ichiro& Tamura, Yasuaki…[et al.]. Growth Inhibition of Re-Challenge B16 Melanoma Transplant by Conjugates of Melanogenesis Substrate and Magnetite Nanoparticles as the Basis for Developing Melanoma-Targeted Chemo-Thermo-Immunotherapy. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-473079
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473079
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر