Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes
المؤلفون المشاركون
Dabrowska, Milena
Lipinska, Danuta
Milewski, Robert
Grubczak, Kamil
Bodzenta-Lukaszyk, Anna
Jeznach, Marta
Rusak, Malgorzata
Bossowski, Artur
Jablonska, Ewa
Górska, Maria
Kretowski, Adam
Milewska, Anna Justyna
Głowińska-Olszewska, Barbara
Moniuszko, Marcin
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Pathobiology of type 1 diabetes (T1D) is predominantly associated with T-cell-related actions.
Homeostasis of majority of T-cells is critically dependent on signals mediated by CD127 (interleukin-7 receptor, IL-7R).
In contrast, regulatory T-cells express very little CD127 and thereby may be delineated by CD4+CD25+CD127− phenotype.
Here we aimed to analyze CD127 expression on CD4+ and CD8+ T-cells and enumerate CD4+CD25+CD127− T-cells in long-lasting T1D.
T-cells were analyzed by flow cytometry and immunologic data were correlated with vascular, metabolic, and inflammatory parameters.
We demonstrated significantly decreased CD127 levels on CD4+, but not CD8+, T cells in T1D pediatric patients.
Interestingly, frequencies of CD4+CD25+CD127− T-cells were significantly enhanced in T1D children and correlated well with frequencies of CD34+CD144+ endothelial progenitor cells and CD4+CD25− T-cells.
Levels of CD127 on both CD4+ and CD8+ T-cells in T1D patients were not correlated to each other or HbA1C.
Interestingly, however, CD127 levels on CD4+ T-cells were significantly correlated to frequencies of CD4+CD25+CD127− T-cells, whereas CD127 levels on CD8+ T-cells were significantly correlated to concentrations of VEGF and triglycerides.
Our data indicate that CD127 expression is differentially modulated on CD4+ and CD8+ T-cells in the course of T1D.
Moreover, we demonstrated that, in contrast to recent-onset T1D, long-lasting T1D is associated with enhancement of T-cells with regulatory phenotype.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moniuszko, Marcin& Głowińska-Olszewska, Barbara& Rusak, Malgorzata& Jeznach, Marta& Grubczak, Kamil& Lipinska, Danuta…[et al.]. 2013. Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-473193
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moniuszko, Marcin…[et al.]. Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes. Clinical and Developmental Immunology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-473193
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moniuszko, Marcin& Głowińska-Olszewska, Barbara& Rusak, Malgorzata& Jeznach, Marta& Grubczak, Kamil& Lipinska, Danuta…[et al.]. Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-473193
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473193
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر