The Diagnostic Value of Transcription Factors T-betGATA3 Ratio in Predicting Antibody-Mediated Rejection
المؤلفون المشاركون
Li, Xue
Chen, Jinsong
Liu, Zhihong
Sun, Qiquan
Zhang, Mingchao
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Previous data showed that the predominance of intraglomerular T-bet or GATA3 is correlated with different mechanisms of rejection, suggesting that the ratio of T-bet/GATA3 might be used to distinguish antibody-mediated rejection (ABMR) and T-cell-mediated rejection (TCMR).
Methods.
We compared the intraglomerular T-bet/GATA3 ratio in ABMR and TCMR.
The intragraft expression of T-bet and GATA3 was studied via immunohistochemistry.
The correlation of the diagnosis of AMR with the ratio of T-bet/GATA3 was examined.
Results.
Both intraglomerular T-bet- and GATA3-expressing cells were increased during acute rejection.
T-bet/GATA3>1 was strongly correlated with ABMR (93.3% versus 18.2%).
The incidence of positive HLA-I/II antibodies and glomerulitis is significantly higher in T-bet/GATA3>1 group (P<0.001, 0.013, resp.).
The scores of peritubular capillary inflammation and glomerulitis were also higher in T-bet/GATA3>1 group (P=0.052, P<0.001, resp.).
Nevertheless, T-bet/GATA3>1 is also correlated with C4d-negative ABMR and resistance to steroid treatment.
Compared with C4d deposition, T-bet/GATA3>1 had a slight lower (90% versus 100%) specificity but a much higher (87.5% versus 68.8%) sensitivity.
Conclusion.
Our data suggested that intraglomerular predominance of T-bet over GATA3 might be used as diagnosis maker of ABMR in addition to C4d, especially in C4d-negative cases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xue& Sun, Qiquan& Zhang, Mingchao& Chen, Jinsong& Liu, Zhihong. 2013. The Diagnostic Value of Transcription Factors T-betGATA3 Ratio in Predicting Antibody-Mediated Rejection. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-473291
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xue…[et al.]. The Diagnostic Value of Transcription Factors T-betGATA3 Ratio in Predicting Antibody-Mediated Rejection. Clinical and Developmental Immunology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-473291
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xue& Sun, Qiquan& Zhang, Mingchao& Chen, Jinsong& Liu, Zhihong. The Diagnostic Value of Transcription Factors T-betGATA3 Ratio in Predicting Antibody-Mediated Rejection. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-473291
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473291
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر