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Bridging the Gap between Fluxomics and Industrial Biotechnology
المؤلفون المشاركون
Feng, Xueyang
Pakrasi, Himadri B.
Colletti, Peter
Page, Lawrence
Tang, Yinjie J.
Chircus, Lauren
Rubens, Jacob
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-02
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Metabolic flux analysis is a vital tool used to determine the ultimate output of cellular metabolism and thus detect biotechnologically relevant bottlenecks in productivity.
13C-based metabolic flux analysis (13C-MFA) and flux balance analysis (FBA) have many potential applications in biotechnology.
However, noteworthy hurdles in fluxomics study are still present.
First, several technical difficulties in both 13C-MFA and FBA severely limit the scope of fluxomics findings and the applicability of obtained metabolic information.
Second, the complexity of metabolic regulation poses a great challenge for precise prediction and analysis of metabolic networks, as there are gaps between fluxomics results and other omics studies.
Third, despite identified metabolic bottlenecks or sources of host stress from product synthesis, it remains difficult to overcome inherent metabolic robustness or to efficiently import and express nonnative pathways.
Fourth, product yields often decrease as the number of enzymatic steps increases.
Such decrease in yield may not be caused by rate-limiting enzymes, but rather is accumulated through each enzymatic reaction.
Fifth, a high-throughput fluxomics tool hasnot been developed for characterizing nonmodel microorganisms and maximizing their application in industrial biotechnology.
Refining fluxomics tools and understanding these obstacles will improve our ability to engineer highlyefficient metabolic pathways in microbial hosts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Feng, Xueyang& Page, Lawrence& Rubens, Jacob& Chircus, Lauren& Colletti, Peter& Pakrasi, Himadri B.…[et al.]. 2011. Bridging the Gap between Fluxomics and Industrial Biotechnology. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-473323
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Feng, Xueyang…[et al.]. Bridging the Gap between Fluxomics and Industrial Biotechnology. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-473323
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Feng, Xueyang& Page, Lawrence& Rubens, Jacob& Chircus, Lauren& Colletti, Peter& Pakrasi, Himadri B.…[et al.]. Bridging the Gap between Fluxomics and Industrial Biotechnology. Journal of Biomedicine and Biotechnology. 2011. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-473323
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473323
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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