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An Update of the Interstitial Cell Compartment in the Normal Human Bladder
المؤلفون المشاركون
Heesakkers, John P. F. A.
Schalken, Jack A.
Hafmans, Theo G. M.
Kuijpers, Kamiel A. J.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aims.
Interstitial cells, also called myofibroblasts, most probably play a major role in the pathogenesis of the overactive bladder.
However, no specific phenotypic marker has been identified.
We investigated whether N-cadherin could play a role as a discriminatory marker for interstitial cells in the human bladder.
Methods.
Bladder biopsies (n = 16) were collected from macroscopically nonpathological locations during cystectomy which was performed because of bladder cancer.
Tissue was analyzed for expression of N-cadherin.
N-cadherin+ cells were phenotyped using antibodies against PGP9.5, smoothelin, vimentin, and C-kit.
Findings were related to bladder tissue histology and ultrastructure of myofibroblastic cells.
Results.
N-cadherin+/vimentin+ cells with branched cell bodies were found in the lamina propria and detrusor layer.
They were closely associated with neurons and showed no colocalization of PGP9.5 or smoothelin.
A second type of N-cadherin+ cells was found at the boundary of detrusor bundles and in the lamina propria.
These cells colocalization C-kit.
We assumed that N-cadherin+/vimentin+ cells are similar to the ultrastructurally defined myofibroblasts.
Conclusions.
N-cadherin can play a role as a discriminatory marker for interstitial cells in the human bladder, as the interstitial compartment of the human bladder houses a population of cells from mesenchymal origin, immunopositive for N-cadherin, vimentin, and C-kit.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuijpers, Kamiel A. J.& Heesakkers, John P. F. A.& Hafmans, Theo G. M.& Schalken, Jack A.. 2014. An Update of the Interstitial Cell Compartment in the Normal Human Bladder. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-473631
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuijpers, Kamiel A. J.…[et al.]. An Update of the Interstitial Cell Compartment in the Normal Human Bladder. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-473631
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuijpers, Kamiel A. J.& Heesakkers, John P. F. A.& Hafmans, Theo G. M.& Schalken, Jack A.. An Update of the Interstitial Cell Compartment in the Normal Human Bladder. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-473631
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473631
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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