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The Ameliorating Effect of Steamed and Fermented Codonopsis lanceolata on Scopolamine-Induced Memory Impairment in Mice
المؤلفون المشاركون
Chung, Jae Youn
Eom, Min Rye
Ma, Choong Je
Chung, Hee-Chul
Kim, Ji-Seon
Lee, Jiwoo
Yun, Bo-Ra
Weon, Jin Bae
Park, Dong-Sik
Lee, Hyeon Yong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Codonopsis lanceolata (Campanulaceae) have been traditionally used to treat lung inflammatory diseases, such as asthma, tonsillitis, and pharyngitis.
The present study was performed to evaluate the cognitive-enhancing effects of steamed and fermented C.
lanceolata in scopolamine-induced memory impairments in mice.
Cognitive abilities were determined by the Morris water maze and passive avoidance tests.
Mice orally received fermented C.
lanceolata extract at doses of 100, 300, or 500 mg/kg body weight.
Fermented C.
lanceolata extract (500 mg/kg body weight, p.o.) significantly shortened the escape latency times that were increased by scopolamine on the 4th day of trial sessions in the Morris water maze task.
In addition, it exerted longer step-through latency times than those of the scopolamine-treated group in the passive avoidance test.
Furthermore, the neuroprotective effects of fermented C.
lanceolata extract on glutamate-induced neurocytotoxicity were investigated in HT22 cells.
Fermented C.
lanceolata extract showed a relative protection ratio of 59.62% at 500 μg/mL.
In conclusion, fermented C.
lanceolata extract ameliorated scopolamine-induced memory impairments, exerted neuroprotective effects, and improved activity compared to that found with original C.
lanceolata.
Further study will be required to investigate the mechanisms underlying this cognitive-enhancing activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Weon, Jin Bae& Yun, Bo-Ra& Lee, Jiwoo& Eom, Min Rye& Kim, Ji-Seon& Lee, Hyeon Yong…[et al.]. 2013. The Ameliorating Effect of Steamed and Fermented Codonopsis lanceolata on Scopolamine-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-473657
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Weon, Jin Bae…[et al.]. The Ameliorating Effect of Steamed and Fermented Codonopsis lanceolata on Scopolamine-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-473657
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Weon, Jin Bae& Yun, Bo-Ra& Lee, Jiwoo& Eom, Min Rye& Kim, Ji-Seon& Lee, Hyeon Yong…[et al.]. The Ameliorating Effect of Steamed and Fermented Codonopsis lanceolata on Scopolamine-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-473657
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473657
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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