Virological Breakthrough : A Risk Factor for Loss to Followup in a Large Community-Based Cohort on Antiretroviral Therapy
المؤلفون المشاركون
Wood, Robin
Orrell, Catherine
Bekker, Linda-Gail
Kaplan, Richard
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
We have previously shown that 75% of individuals on antiretroviral therapy (ART) in a resource-limited setting who experienced virological breakthrough to >1000 copies/mL were resuppressed after an intensive adherence intervention.
This study examines the long-term outcomes of this group in order to understand the impact of the adherence intervention over time.
Methods.
ART-naïve adults commencing ART between September 2002 and December 2009 were reviewed.
Those who achieved suppression (<50 copies/mL) were categorised by subsequent viral load: any >1000 copies/mL (virological breakthrough) or not.
Those with breakthrough were sub-categorised by following viral load into failed (VL > 1000 copies/mL) or resuppressed (VL < 1000 copies/mL).
Their outcome (lost-to follow-up, death, in care on first-line therapy or in care on second-line therapy) was determined as of the 13th April 2010.
Findings.
4047 ART-naïve adults commenced ART.
3086 had >2 viral loads and were included in the analysis.
2959 achieved virological suppression (96%).
Thereafter 2109 (71%) remained suppressed and 850 (29%) experienced breakthrough (n=283 (33%) failed and n=567 (67%) resuppressed).
Individuals with breakthrough were younger (P<.001), had lower CD4 counts (P<.001), and higher viral loads (P<.001) than those who remained suppressed.
By 7 years the risk of breakthrough was 42% and of failure 15%.
Fewer adults with breakthrough remain in care over time (P<.001).
Loss to care is similar whether the individuals failed or resuppressed.
Interpretation.
While 67% of those who experience initial virological breakthrough resuppress after an adherence intervention, these individuals are significantly less likely be retained in care than those who remain virologically suppressed throughout.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Orrell, Catherine& Kaplan, Richard& Wood, Robin& Bekker, Linda-Gail. 2011. Virological Breakthrough : A Risk Factor for Loss to Followup in a Large Community-Based Cohort on Antiretroviral Therapy. AIDS Research and Treatment،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473952
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Orrell, Catherine…[et al.]. Virological Breakthrough : A Risk Factor for Loss to Followup in a Large Community-Based Cohort on Antiretroviral Therapy. AIDS Research and Treatment No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-473952
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Orrell, Catherine& Kaplan, Richard& Wood, Robin& Bekker, Linda-Gail. Virological Breakthrough : A Risk Factor for Loss to Followup in a Large Community-Based Cohort on Antiretroviral Therapy. AIDS Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473952
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473952
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر