An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor
المؤلفون المشاركون
Liu, Chen
Kojima, Angerika Y.
Reith, John D.
Vila Duckworth, Lizette
Jacob, Sanjivini V.
Williams, William D.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-18
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Systemic inflammatory myofibroblastic tumor is an exceedingly rare entity.
A 45-year-old Hispanic female presented with a 6-month history of left-sided thigh pain, low back pain, and generalized weakness.
PET/CT scan revealed abnormal activity in the liver, adrenal gland, and pancreas.
MRI of the abdomen demonstrated two 6-7 cm masses in the liver.
MRI of the lumbar spine demonstrated lesions in the L2 to L4 spinous processes, paraspinal muscles, and subcutaneous tissues, as well as an 8 mm enhancing intradural lesion at T11, all thought to be metastatic disease.
A biopsy of the liver showed portal tract expansion by a spindle cell proliferation rich in inflammation.
Tumor cells showed immunoreactivity for smooth muscle actin and anaplastic lymphoma kinase 1 (ALK1).
Tissue from the L5 vertebra showed a process histologically identical to that seen in the liver.
FISH analysis of these lesions demonstrated an ALK (2p23) gene rearrangement.
The patient was successfully treated with an ALK-inhibitor, Crizotinib, and is now in complete remission.
We present the first reported case, to our knowledge, of inflammatory myofibroblastic tumor with systemic manifestations and ALK translocation.
This case is a prime example of how personalized medicine has vastly improved patient care through the use of molecular-targeted therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jacob, Sanjivini V.& Reith, John D.& Kojima, Angerika Y.& Williams, William D.& Liu, Chen& Vila Duckworth, Lizette. 2014. An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor. Case Reports in Pathology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-474048
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jacob, Sanjivini V.…[et al.]. An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor. Case Reports in Pathology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-474048
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jacob, Sanjivini V.& Reith, John D.& Kojima, Angerika Y.& Williams, William D.& Liu, Chen& Vila Duckworth, Lizette. An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor. Case Reports in Pathology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-474048
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474048
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر