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An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor
المؤلفون المشاركون
Liu, Chen
Kojima, Angerika Y.
Reith, John D.
Vila Duckworth, Lizette
Jacob, Sanjivini V.
Williams, William D.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-18
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Systemic inflammatory myofibroblastic tumor is an exceedingly rare entity.
A 45-year-old Hispanic female presented with a 6-month history of left-sided thigh pain, low back pain, and generalized weakness.
PET/CT scan revealed abnormal activity in the liver, adrenal gland, and pancreas.
MRI of the abdomen demonstrated two 6-7 cm masses in the liver.
MRI of the lumbar spine demonstrated lesions in the L2 to L4 spinous processes, paraspinal muscles, and subcutaneous tissues, as well as an 8 mm enhancing intradural lesion at T11, all thought to be metastatic disease.
A biopsy of the liver showed portal tract expansion by a spindle cell proliferation rich in inflammation.
Tumor cells showed immunoreactivity for smooth muscle actin and anaplastic lymphoma kinase 1 (ALK1).
Tissue from the L5 vertebra showed a process histologically identical to that seen in the liver.
FISH analysis of these lesions demonstrated an ALK (2p23) gene rearrangement.
The patient was successfully treated with an ALK-inhibitor, Crizotinib, and is now in complete remission.
We present the first reported case, to our knowledge, of inflammatory myofibroblastic tumor with systemic manifestations and ALK translocation.
This case is a prime example of how personalized medicine has vastly improved patient care through the use of molecular-targeted therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jacob, Sanjivini V.& Reith, John D.& Kojima, Angerika Y.& Williams, William D.& Liu, Chen& Vila Duckworth, Lizette. 2014. An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor. Case Reports in Pathology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-474048
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jacob, Sanjivini V.…[et al.]. An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor. Case Reports in Pathology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-474048
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jacob, Sanjivini V.& Reith, John D.& Kojima, Angerika Y.& Williams, William D.& Liu, Chen& Vila Duckworth, Lizette. An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor. Case Reports in Pathology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-474048
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474048
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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