Anti-Inflammatory Potential of Ethanolic Leaf Extract of Eupatorium adenophorum Spreng. Through Alteration in Production of TNF-α, ROS and Expression of Certain Genes
المؤلفون المشاركون
Chatterjee, Shankar N.
Mazumder, Tamal
Chakravarty, Ashim K.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Search for a novel anti-inflammatory agent from a herbal source, such as Eupatorium adenophorum Spreng., a plant from the Eastern Himalayas, is of prime interest in the present investigation.
Inflammation causes tissue destruction and development of diseases such as asthma, rheumatoid arthritis, and so forth.
The ethanolic leaf extract of E.
adenophorum (EEA) was administered intravenously and in other cases topically at the site of delayed type hypersensitivity (DTH) reaction in mouse foot paw induced with dinitrofluorobenzene.
EEA can effectively inhibit DTH reaction and bring back normalcy to the paw much earlier than the controls.
Efficacy of EEA on regulatory mechanisms for inflammation has also been considered.
Intravenous administration of EEA increased the number of CD4+ T cells in spleen and tumor necrosis factor (TNF)-α in serum of DTH mice.
Initially it was difficult to reconcile with the anti-inflammatory role of EEA and simultaneous induction of TNF-α, an established pro-inflammatory cytokine.
EEA induces higher expression of TNF-α gene and amount of the cytokine in serum.
We discussed the other role of TNF-α, its involvement in repairing tissue damage incurred in course of inflammatory reaction.
EEA also induces TGF-β encoding a cytokine involved in tissue repair mechanism.
EEA inhibits expression of another pro-inflammatory cytokine gene IL-1β and downregulates cycloxygenase 2 (COX2) gene responsible for metabolism of inflammatory mediators like prostaglandins.
Furthermore, anti-inflammatory role of EEA is also revealed through its inhibition of hydroxyl radical generation.
Notably EEA does not necessarily affect the expression of other inflammation-related genes such as IL-6, IL-10 and IKK.
The present study reports and analyzes for the first time the anti-inflammatory property of the leaf extract of E.
adenophorum.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chakravarty, Ashim K.& Mazumder, Tamal& Chatterjee, Shankar N.. 2011. Anti-Inflammatory Potential of Ethanolic Leaf Extract of Eupatorium adenophorum Spreng. Through Alteration in Production of TNF-α, ROS and Expression of Certain Genes. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-474106
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chakravarty, Ashim K.…[et al.]. Anti-Inflammatory Potential of Ethanolic Leaf Extract of Eupatorium adenophorum Spreng. Through Alteration in Production of TNF-α, ROS and Expression of Certain Genes. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-474106
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chakravarty, Ashim K.& Mazumder, Tamal& Chatterjee, Shankar N.. Anti-Inflammatory Potential of Ethanolic Leaf Extract of Eupatorium adenophorum Spreng. Through Alteration in Production of TNF-α, ROS and Expression of Certain Genes. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-474106
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474106
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر