Effect of Gender on Coagulation Functions : A Study in Metastatic Colorectal Cancer Patients Treated with Bevacizumab, Irinotecan, 5-Fluorouracil, and Leucovorin
المؤلفون المشاركون
Bilir, Cemil
Temi, Yasemin Bakkal
Engin, Hüseyin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-21
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction.
We designed this study to evaluate how coagulation parameters are changed in metastatic colorectal cancer (mCRC) patients treated with bevacizumab, irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI).
Methods.
A total of 48 mCRC patients who initially received bevacizumab with FOLFIRI were eligible for this study.
Thirty-four patients were analyzed at baseline and on the 4th, 8th, and 12th cycles of chemotherapy.
Results.
There were 19 male and 15 female patients.
Baseline characteristics of the groups were similar, but women had better overall survival than men (14 months versus 12 months, P=0.044).
D-dimer levels decreased significantly after the 12th cycle compared with baseline in men but not in women.
Men and women had increased levels of serum fibrinogen at the early cycles, but these increased fibrinogen levels continued after the 4th cycle of chemotherapy only in women.
In addition, serum fibrinogen levels did not significantly change, but aPTT levels decreased in men.
Discussion.
The major finding of this study is that bevacizumab-FOLFIRI chemotherapy does not promote changes in the coagulation system.
If chemotherapy treatment and the possible side effects of FOLFIRI-bevacizumab treatment are well managed, then alterations of the coagulation cascade will not have an impact on overall survival and mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bilir, Cemil& Engin, Hüseyin& Temi, Yasemin Bakkal. 2014. Effect of Gender on Coagulation Functions : A Study in Metastatic Colorectal Cancer Patients Treated with Bevacizumab, Irinotecan, 5-Fluorouracil, and Leucovorin. Advances in Hematology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-474329
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bilir, Cemil…[et al.]. Effect of Gender on Coagulation Functions : A Study in Metastatic Colorectal Cancer Patients Treated with Bevacizumab, Irinotecan, 5-Fluorouracil, and Leucovorin. Advances in Hematology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-474329
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bilir, Cemil& Engin, Hüseyin& Temi, Yasemin Bakkal. Effect of Gender on Coagulation Functions : A Study in Metastatic Colorectal Cancer Patients Treated with Bevacizumab, Irinotecan, 5-Fluorouracil, and Leucovorin. Advances in Hematology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-474329
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474329
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر