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Rubi Fructus (Rubus coreanus) Inhibits Differentiation to Adipocytes in 3T3-L1 Cells
المؤلفون المشاركون
Kim, Hye-Lin
Park, Jinbong
So, Hong-Seob
Jeong, Mi-Young
Hong, Seung-Heon
Park, Raekil
Kim, Su-Jin
Um, Jae-Young
An, Hyo-Jin
Kim, Sung-Hoon
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Rubi Fructus (RF) is known to exert several pharmacological effects including antitumor, antioxidant, and anti-inflammatory activities.
However, its antiobesity effect has not been reported yet.
This study was focused on the antidifferentiation effect of RF extract on 3T3-L1 preadipocytes.
When 3T3-L1 preadipocytes were differentiating into adipocytes, 10–100 μg/mL of RF was added.
Next, the lipid contents were quantified by Oil Red O staining.
RF significantly reduced lipid accumulation and downregulated the expression of peroxisome proliferator-activated receptor γ (PPARγ), CCAAT0-enhancer-binding proteins α (C/EBPα), adipocyte fatty acid-binding protein 2 (aP2), resistin, and adiponectin in ways that were concentration dependent.
Moreover, RF markedly upregulated liver kinase B1 and AMP-activated protein kinase (AMPK).
Interestingly, pretreatment with AMPKα siRNA and RF downregulated the expression of PPARγ and C/EBPα protein as well as the adipocyte differentiation.
Our study shows that RF is capable of inhibiting the differentiation of 3T3-L1 adipocytes through the modulation of PPARγ, C/EBPα, and AMPK, suggesting that it has a potential for therapeutic application in the treatment or prevention of obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jeong, Mi-Young& Kim, Hye-Lin& Park, Jinbong& An, Hyo-Jin& Kim, Sung-Hoon& Kim, Su-Jin…[et al.]. 2013. Rubi Fructus (Rubus coreanus) Inhibits Differentiation to Adipocytes in 3T3-L1 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-474523
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jeong, Mi-Young…[et al.]. Rubi Fructus (Rubus coreanus) Inhibits Differentiation to Adipocytes in 3T3-L1 Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-474523
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jeong, Mi-Young& Kim, Hye-Lin& Park, Jinbong& An, Hyo-Jin& Kim, Sung-Hoon& Kim, Su-Jin…[et al.]. Rubi Fructus (Rubus coreanus) Inhibits Differentiation to Adipocytes in 3T3-L1 Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-474523
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474523
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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