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In Silico Analysis of β-Galactosidases Primary and Secondary Structure in relation to Temperature Adaptation
المؤلفون المشاركون
Kumar, Vijay
Sharma, Nikhil
Bhalla, Tek Chand
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
β-D-Galactosidases (EC 3.2.1.23) hydrolyze the terminal nonreducing β-D-galactose residues in β-D-galactosides and are ubiquitously present in all life forms including extremophiles.
Eighteen microbial β-galactosidase protein sequences, six each from psychrophilic, mesophilic, and thermophilic microbes, were analyzed.
Primary structure reveals alanine, glycine, serine, and arginine to be higher in psychrophilic β-galactosidases whereas valine, glutamine, glutamic acid, phenylalanine, threonine, and tyrosine are found to be statistically preferred by thermophilic β-galactosidases.
Cold active β-galactosidase has a strong preference towards tiny and small amino acids, whereas high temperature inhabitants had higher content of basic and aromatic amino acids.
Thermophilic β-galactosidases have higher percentage of α-helix region responsible for temperature tolerance while cold loving β-galactosidases had higher percentage of sheet and coil region.
Secondary structure analysis revealed that charged and aromatic amino acids were significant for sheet region of thermophiles.
Alanine was found to be significant and high in the helix region of psychrophiles and valine counters in thermophilic β-galactosidase.
Coil region of cold active β-galactosidase has higher content of tiny amino acids which explains their high catalytic efficiency over their counterparts from thermal habitat.
The present study has revealed the preference or prevalence of certain amino acids in primary and secondary structure of psychrophilic, mesophilic, and thermophilic β-galactosidase.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kumar, Vijay& Sharma, Nikhil& Bhalla, Tek Chand. 2014. In Silico Analysis of β-Galactosidases Primary and Secondary Structure in relation to Temperature Adaptation. Journal of Amino Acids،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-474563
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kumar, Vijay…[et al.]. In Silico Analysis of β-Galactosidases Primary and Secondary Structure in relation to Temperature Adaptation. Journal of Amino Acids No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-474563
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kumar, Vijay& Sharma, Nikhil& Bhalla, Tek Chand. In Silico Analysis of β-Galactosidases Primary and Secondary Structure in relation to Temperature Adaptation. Journal of Amino Acids. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-474563
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474563
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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