Inflammatory Animal Model for Parkinson's Disease : The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons
المؤلفون المشاركون
Herrera, Antonio
de Pablos, R. M.
Sarmiento, M.
Venero, J. L.
Cano, J.
Espinosa-Oliva, A. M.
Villarán, R. F.
Delgado-Cortés, M. J.
Arguelles, Sandro
Mauriño, R.
Machado, A.
Santiago, M.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-17
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
We have developed an animal model of degeneration of the nigrostriatal dopaminergic neurons, the neuronal system involved in Parkinson's disease (PD).
The implication of neuroinflammation on this disease was originally established in 1988, when the presence of activated microglia in the substantia nigra (SN) of parkinsonians was reported by McGeer et al.
Neuroinflammation could be involved in the progression of the disease or even has more direct implications.
We injected 2 μg of the potent proinflammatory compound lipopolysaccharide (LPS) in different areas of the CNS, finding that SN displayed the highest inflammatory response and that dopaminergic (body) neurons showed a special and specific sensitivity to this process with the induction of selective dopaminergic degeneration.
Neurodegeneration is induced by inflammation since it is prevented by anti-inflammatory compounds.
The special sensitivity of dopaminergic neurons seems to be related to the endogenous dopaminergic content, since it is overcome by dopamine depletion.
Compounds that activate microglia or induce inflammation have similar effects to LPS.
This model suggest that inflammation is an important component of the degeneration of the nigrostriatal dopaminergic system, probably also in PD.
Anti-inflammatory treatments could be useful to prevent or slow down the rate of dopaminergic degeneration in this disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Machado, A.& Herrera, Antonio& Venero, J. L.& Santiago, M.& de Pablos, R. M.& Villarán, R. F.…[et al.]. 2011. Inflammatory Animal Model for Parkinson's Disease : The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons. ISRN Neurology،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-474597
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Machado, A.…[et al.]. Inflammatory Animal Model for Parkinson's Disease : The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons. ISRN Neurology No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-474597
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Machado, A.& Herrera, Antonio& Venero, J. L.& Santiago, M.& de Pablos, R. M.& Villarán, R. F.…[et al.]. Inflammatory Animal Model for Parkinson's Disease : The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons. ISRN Neurology. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-474597
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474597
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر