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Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes : A Comparative Study
المؤلفون المشاركون
Pfeilschifter, Josef
Müller, Elke
Schürmann, Christoph
Frank, Stefan
Goren, Itamar
Hermes, Nadine
Seitz, Oliver
المصدر
Experimental Diabetes Research
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-20
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
In the past, the genetically diabetic-obese diabetes/diabetes (db/db) and obese/obese (ob/ob) mouse strains were used to investigate mechanisms of diabetes-impaired wound healing.
Here we determined patterns of skin repair in genetically normal C57Bl/6J mice that were fed using a high fat diet (HFD) to induce a diabetes-obesity syndrome.
Wound closure was markedly delayed in HFD-fed mice compared to mice which had received a standard chow diet (CD).
Impaired wound tissue of HFD mice showed a marked prolongation of wound inflammation.
Expression of vascular endothelial growth factor (VEGF) was delayed and associated with the disturbed formation of wound margin epithelia and an impaired angiogenesis in the reduced granulation tissue.
Normal wound contraction was retarded and disordered.
Wound disorders in obese C57Bl/6J mice were paralleled by a prominent degradation of the inhibitor of NFκB (IκB-α) in the absence of an Akt activation.
By contrast to impaired wound conditions in ob/ob mice, late wounds of HFD mice did not develop a chronic inflammatory state and were epithelialized after 11 days of repair.
Thus, only genetically obese and diabetic ob/ob mice finally developed chronic wounds and therefore represent a better suited experimental model to investigate diabetes-induced wound healing disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Seitz, Oliver& Schürmann, Christoph& Hermes, Nadine& Müller, Elke& Pfeilschifter, Josef& Frank, Stefan…[et al.]. 2011. Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes : A Comparative Study. Experimental Diabetes Research،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-474678
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Seitz, Oliver…[et al.]. Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes : A Comparative Study. Experimental Diabetes Research No. 2010 (2010), pp.1-15.
https://search.emarefa.net/detail/BIM-474678
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Seitz, Oliver& Schürmann, Christoph& Hermes, Nadine& Müller, Elke& Pfeilschifter, Josef& Frank, Stefan…[et al.]. Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes : A Comparative Study. Experimental Diabetes Research. 2011. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-474678
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474678
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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