Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, andor Infertility : Etiology and Clinical Manifestations
المؤلفون المشاركون
Chinolla-Arellano, Lizbeth Zarela
Leaños-Miranda, Alfredo
Campos-Galicia, Inova
Chang-Verdugo, Rosario
Ramírez-Valenzuela, Karla Leticia
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
To determine the frequency of macroprolactinemia, its etiology, and the clinical manifestations in patients with hyperprolactinemia presenting with menstrual irregularities, galactorrhea, and/or infertility who were attended by the gynecology-endocrinology service.
Methods.
In a cross-sectional study, 326 hyperprolactinemic women were tested for serum prolactin (PRL) concentrations before and after chromatographic separation (gel filtration and affinity with protein G) and extraction of free PRL with polyethylene glycol (PEG).
Results.
Sera from 57 patients (17.5%) were found to have macroprolactinemia.
The presence of macroprolactinemia was attributable to anti-PRL autoantibodies in 54 (94.7%) patients.
The median serum PRL levels were similar in patients with or without macroprolactinemia (42.0 versus 38.1 ng/mL).
In contrast, patients with macroprolactinemia had lower serum-free PRL levels (median 9.2 versus 31.7 ng/mL, P<0.001).
Patients without macroprolactinemia had a higher frequency of galactorrhea and abnormal pituitary imagine findings (P<0.002).
Conclusions.
We can conclude that macroprolactinemia should be considered as a benign variant, and it must be ruled out in women presenting with menstrual irregularities, galactorrhea, and/or infertility in order to investigate other causes different than hyperprolactinemia.
Serum PRL precipitated with PEG is a convenient and simple procedure to screen for the presence of macroprolactinemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leaños-Miranda, Alfredo& Ramírez-Valenzuela, Karla Leticia& Campos-Galicia, Inova& Chang-Verdugo, Rosario& Chinolla-Arellano, Lizbeth Zarela. 2013. Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, andor Infertility : Etiology and Clinical Manifestations. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-474706
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leaños-Miranda, Alfredo…[et al.]. Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, andor Infertility : Etiology and Clinical Manifestations. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-474706
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leaños-Miranda, Alfredo& Ramírez-Valenzuela, Karla Leticia& Campos-Galicia, Inova& Chang-Verdugo, Rosario& Chinolla-Arellano, Lizbeth Zarela. Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, andor Infertility : Etiology and Clinical Manifestations. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-474706
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474706
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر