Investigation of Super Learner Methodology on HIV-1 Small Sample : Application on Jaguar Trial Data
المؤلفون المشاركون
Marcelin, Anne-Geneviève
Houssaïni, Allal
Calvez, Vincent
Assoumou, Lambert
Molina, Jean Michel
Flandre, Philippe
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Many statistical models have been tested to predict phenotypic or virological response from genotypic data.
A statistical framework called Super Learner has been introduced either to compare different methods/learners (discrete Super Learner) or to combine them in a Super Learner prediction method.
Methods.
The Jaguar trial is used to apply the Super Learner framework.
The Jaguar study is an “add-on” trial comparing the efficacy of adding didanosine to an on-going failing regimen.
Our aim was also to investigate the impact on the use of different cross-validation strategies and different loss functions.
Four different repartitions between training set and validations set were tested through two loss functions.
Six statistical methods were compared.
We assess performance by evaluating R2 values and accuracy by calculating the rates of patients being correctly classified.
Results.
Our results indicated that the more recent Super Learner methodology of building a new predictor based on a weighted combination of different methods/learners provided good performance.
A simple linear model provided similar results to those of this new predictor.
Slight discrepancy arises between the two loss functions investigated, and slight difference arises also between results based on cross-validated risks and results from full dataset.
The Super Learner methodology and linear model provided around 80% of patients correctly classified.
The difference between the lower and higher rates is around 10 percent.
The number of mutations retained in different learners also varys from one to 41.
Conclusions.
The more recent Super Learner methodology combining the prediction of many learners provided good performance on our small dataset.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Houssaïni, Allal& Assoumou, Lambert& Marcelin, Anne-Geneviève& Molina, Jean Michel& Calvez, Vincent& Flandre, Philippe. 2012. Investigation of Super Learner Methodology on HIV-1 Small Sample : Application on Jaguar Trial Data. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-474723
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Houssaïni, Allal…[et al.]. Investigation of Super Learner Methodology on HIV-1 Small Sample : Application on Jaguar Trial Data. AIDS Research and Treatment No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-474723
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Houssaïni, Allal& Assoumou, Lambert& Marcelin, Anne-Geneviève& Molina, Jean Michel& Calvez, Vincent& Flandre, Philippe. Investigation of Super Learner Methodology on HIV-1 Small Sample : Application on Jaguar Trial Data. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-474723
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474723
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر