An Observational Study on Early Empiric versus Culture-Directed Antifungal Therapy in Critically Ill with Intra-Abdominal Sepsis
المؤلفون المشاركون
Kwa, Andrea Lay Hoon
Liew, Yixin
Chlebicki, Maciej Piotr
Lee, Winnie Hui Ling
Lee, Pang
Ong, Sharon
المصدر
Critical Care Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To compare early empiric antifungal treatment with culture-directed treatment in critically ill patients with intra-abdominal sepsis.
Methods.
A prospective observational cohort study was conducted between August 2010 and July 2011, on SICU patients admitted after surgery for gastrointestinal perforation, bowel obstruction or ischemia, malignancy and anastomotic leakages.
Patients who received antifungal treatment within two days of sepsis onset were compared to patients who received culture-directed antifungal treatment in terms of mortality rate and clinical improvement.
Patients’ demographics, comorbidities, severity-of-illness scores, and laboratory results were systematically collected and analysed.
Results.
Thirty-three patients received early empiric and 19 received culture-directed therapy.
Of these, 30 from the early empiric group and 18 from culture-directed group were evaluable and analysed.
Both groups had similar baseline characteristics and illness severity.
Patients on empiric antifungal use had significantly lower 30-day mortality (P=0.03) as well as shorter median time to clinical improvement (P=0.025).
Early empiric antifungal therapy was independently associated with survival beyond 30 days (OR 0.131, 95% CI: 0.018 to 0.966; P=0.046).
Conclusion.
Early empiric antifungal therapy in surgical patients with intra-abdominal sepsis was associated with reduced mortality and warrants further evaluation in randomised controlled trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Winnie Hui Ling& Liew, Yixin& Chlebicki, Maciej Piotr& Ong, Sharon& Lee, Pang& Kwa, Andrea Lay Hoon. 2014. An Observational Study on Early Empiric versus Culture-Directed Antifungal Therapy in Critically Ill with Intra-Abdominal Sepsis. Critical Care Research and Practice،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-474814
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Winnie Hui Ling…[et al.]. An Observational Study on Early Empiric versus Culture-Directed Antifungal Therapy in Critically Ill with Intra-Abdominal Sepsis. Critical Care Research and Practice No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-474814
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Winnie Hui Ling& Liew, Yixin& Chlebicki, Maciej Piotr& Ong, Sharon& Lee, Pang& Kwa, Andrea Lay Hoon. An Observational Study on Early Empiric versus Culture-Directed Antifungal Therapy in Critically Ill with Intra-Abdominal Sepsis. Critical Care Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-474814
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474814
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر