Three-Year Successful Cinacalcet Treatment of Secondary Hyperparathyroidism in a Patient with X-Linked Dominant Hypophosphatemic Rickets : A Case Report
المؤلفون المشاركون
Grove-Laugesen, Diana
Rejnmark, Lars
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-10
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Hypophosphatemic rickets (HR) is a rare inherited disorder characterized by a classic rickets phenotype with low plasma phosphate levels and resistance to treatment with vitamin D.
Development of secondary hyperparathyroidism (SHPT) as a direct consequence of treatment is a frequent complication and a major clinical challenge, as this may increase risk of further comorbidity.
Cinacalcet, a calcimimetic agent that reduces the secretion of PTH from the parathyroid glands, has been suggested as adjuvant treatment to SHPT in patients with HR.
However, only two papers have previously been published and no data are available on effects of treatment for more than six months.
We now report a case of 3-year treatment with cinacalcet in a patient with HR complicated by SHPT.
A 53-year-old woman with genetically confirmed X-linked dominant hypophosphatemic rickets developed SHPT after 25 years of conventional treatment with alfacalcidol and phosphate supplements.
Cinacalcet was added to her treatment, causing a sustained normalization of PTH.
Ionized calcium decreased, requiring reduction of cinacalcet, though asymptomatical.
Level of phosphate was unchanged, but alkaline phosphatase increased in response to treatment.
Cinacalcet appeared to be efficient, safe, and well tolerated.
We recommend close control of plasma calcium to avoid hypocalcemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Grove-Laugesen, Diana& Rejnmark, Lars. 2014. Three-Year Successful Cinacalcet Treatment of Secondary Hyperparathyroidism in a Patient with X-Linked Dominant Hypophosphatemic Rickets : A Case Report. Case Reports in Endocrinology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-474835
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Grove-Laugesen, Diana& Rejnmark, Lars. Three-Year Successful Cinacalcet Treatment of Secondary Hyperparathyroidism in a Patient with X-Linked Dominant Hypophosphatemic Rickets : A Case Report. Case Reports in Endocrinology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-474835
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Grove-Laugesen, Diana& Rejnmark, Lars. Three-Year Successful Cinacalcet Treatment of Secondary Hyperparathyroidism in a Patient with X-Linked Dominant Hypophosphatemic Rickets : A Case Report. Case Reports in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-474835
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-474835
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر