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Radioiodine Thyroid Remnant Ablation after Recombinant Human Thyrotropin or Thyroid Hormone Withdrawal in Patients with High-Risk Differentiated Thyroid Cancer
المؤلفون المشاركون
Abelleira, Erika
Lutfi, Rubén Julio
Pitoia, Fabián
Marlowe, Robert J.
Niepomniszcze, Hugo
Faure, Eduardo N.
Bueno, Fernanda
Schwarzstein, Diego
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
To supplement limited relevant literature, we retrospectively compared ablation and disease outcomes in high-risk differentiated thyroid carcinoma (DTC) patients undergoing radioiodine thyroid remnant ablation aided by recombinant human thyrotropin (rhTSH) versus thyroid hormone withdrawal/withholding (THW).
Our cohort was 45 consecutive antithyroglobulin antibody- (TgAb-) negative, T3-T4/N0-N1-Nx/M0 adults ablated with high activities at three referral centers.
Ablation success comprised negative (<1 μg/L) stimulated serum thyroglobulin (Tg) and TgAb, with absent or <0.1% scintigraphic thyroid bed uptake.
“No evidence of disease” (NED) comprised negative unstimulated/stimulated Tg and no suspicious neck ultrasonography or pathological imaging or biopsy.
“Persistent disease” was failure to achieve NED, “recurrence,” loss of NED status.
rhTSH patients (n=18) were oftener ≥45 years old and higher stage (P=0.01), but otherwise not different than THW patients (n=27) at baseline.
rhTSH patients were significantly oftener successfully ablated compared to THW patients (83% versus 67%, P<0.02).
After respective 3.3 yr and 4.5 yr mean follow-ups (P=0.02), NED was achieved oftener (72% versus 59%) and persistent disease was less frequent in rhTSH patients (22% versus 33%) (both comparisons P=0.03).
rhTSH stimulation is associated with at least as good outcomes as is THW in ablation of high-risk DTC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pitoia, Fabián& Marlowe, Robert J.& Abelleira, Erika& Faure, Eduardo N.& Bueno, Fernanda& Schwarzstein, Diego…[et al.]. 2012. Radioiodine Thyroid Remnant Ablation after Recombinant Human Thyrotropin or Thyroid Hormone Withdrawal in Patients with High-Risk Differentiated Thyroid Cancer. Journal of Thyroid Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475016
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pitoia, Fabián…[et al.]. Radioiodine Thyroid Remnant Ablation after Recombinant Human Thyrotropin or Thyroid Hormone Withdrawal in Patients with High-Risk Differentiated Thyroid Cancer. Journal of Thyroid Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-475016
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pitoia, Fabián& Marlowe, Robert J.& Abelleira, Erika& Faure, Eduardo N.& Bueno, Fernanda& Schwarzstein, Diego…[et al.]. Radioiodine Thyroid Remnant Ablation after Recombinant Human Thyrotropin or Thyroid Hormone Withdrawal in Patients with High-Risk Differentiated Thyroid Cancer. Journal of Thyroid Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475016
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475016
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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