Inhibitory Effects of Glycyrrhetinic Acid on the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes and HERG Channel

المؤلفون المشاركون

Jiang, Linqing
Wu, Delin
Ren, Jianxun
Wu, Hongjin
Liu, Yuna
Chen, Xianbing
Wang, Shengqi
Zheng, Sidao
Yang, Jiyuan

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-08-29

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

Licorice has long been used to treat many ailments including cardiovascular disorders in China.

Recent studies have shown that the cardiac actions of licorice can be attributed to its active component, glycyrrhetinic acid (GA).

However, the mechanism of action remains poorly understood.

Aim.

The effects of GA on the delayed rectifier potassium current (IK), the rapidly activating (IKr) and slowly activating (IKs) components of IK, and the HERG K+ channel expressed in HEK-293 cells were investigated.

Materials and Methods.

Single ventricular myocytes were isolated from guinea pig myocardium using enzymolysis.

The wild type HERG gene was stably expressed in HEK293 cells.

Whole-cell patch clamping was used to record IK (IKr, IKs) and the HERG K+ current.

Results.

GA (1, 5, and 10 μM) inhibited IK (IKr, IKs) and the HERG K+ current in a concentration-dependent manner.

Conclusion.

GA significantly inhibited the potassium currents in a dose- and voltage-dependent manner, suggesting that it exerts its antiarrhythmic action through the prolongation of APD and ERP owing to the inhibition of IK (IKr, IKs) and HERG K+ channel.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wu, Delin& Jiang, Linqing& Wu, Hongjin& Wang, Shengqi& Zheng, Sidao& Yang, Jiyuan…[et al.]. 2013. Inhibitory Effects of Glycyrrhetinic Acid on the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes and HERG Channel. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-475039

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wu, Delin…[et al.]. Inhibitory Effects of Glycyrrhetinic Acid on the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes and HERG Channel. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-475039

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wu, Delin& Jiang, Linqing& Wu, Hongjin& Wang, Shengqi& Zheng, Sidao& Yang, Jiyuan…[et al.]. Inhibitory Effects of Glycyrrhetinic Acid on the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes and HERG Channel. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-475039

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-475039