Microwave Assisted Enzymatic Kinetic Resolution of (±)-1-Phenyl-2-propyn-1-ol in Nonaqueous Media
المؤلفون المشاركون
Devendran, Saravanan
Yadav, Ganapati D.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Kinetic resolution of 1-phenyl-2-propyn-1-ol, an important chiral synthon, was studied through trans-esterification with acyl acetate to investigate synergism between microwave irradiation and enzyme catalysis.
Lipases from different microbial origins were employed for the kinetic resolution of (R/S)-1-phenyl-2-propyn-1-ol, among which Candida antarctica lipase B, immobilized on acrylic resin (Novozym 435), was found to be the best catalyst in n-hexane as solvent.
Vinyl acetate was the most effective among different acyl esters studied.
The effect of various parameters was studied in a systematic manner.
Definite synergism between microwave and enzyme was observed.
The initial rate was improved around 1.28 times under microwave irradiation than conventional heating.
Under optimum conditions, maximum conversion (48.78%) and high enantiomeric excess (93.25%) were obtained in 2 h.
From modeling studies, it is concluded that the reaction follows the Ping-Pong bi-bi mechanism with dead end alcohol inhibition.
Kinetic parameters were obtained by using nonlinear regression.
This process is green, clean, and easily scalable as compared to the chemical process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Devendran, Saravanan& Yadav, Ganapati D.. 2014. Microwave Assisted Enzymatic Kinetic Resolution of (±)-1-Phenyl-2-propyn-1-ol in Nonaqueous Media. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-475120
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Devendran, Saravanan& Yadav, Ganapati D.. Microwave Assisted Enzymatic Kinetic Resolution of (±)-1-Phenyl-2-propyn-1-ol in Nonaqueous Media. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-475120
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Devendran, Saravanan& Yadav, Ganapati D.. Microwave Assisted Enzymatic Kinetic Resolution of (±)-1-Phenyl-2-propyn-1-ol in Nonaqueous Media. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-475120
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475120
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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