Microwave Assisted Enzymatic Kinetic Resolution of (±)-1-Phenyl-2-propyn-1-ol in Nonaqueous Media
Joint Authors
Devendran, Saravanan
Yadav, Ganapati D.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Kinetic resolution of 1-phenyl-2-propyn-1-ol, an important chiral synthon, was studied through trans-esterification with acyl acetate to investigate synergism between microwave irradiation and enzyme catalysis.
Lipases from different microbial origins were employed for the kinetic resolution of (R/S)-1-phenyl-2-propyn-1-ol, among which Candida antarctica lipase B, immobilized on acrylic resin (Novozym 435), was found to be the best catalyst in n-hexane as solvent.
Vinyl acetate was the most effective among different acyl esters studied.
The effect of various parameters was studied in a systematic manner.
Definite synergism between microwave and enzyme was observed.
The initial rate was improved around 1.28 times under microwave irradiation than conventional heating.
Under optimum conditions, maximum conversion (48.78%) and high enantiomeric excess (93.25%) were obtained in 2 h.
From modeling studies, it is concluded that the reaction follows the Ping-Pong bi-bi mechanism with dead end alcohol inhibition.
Kinetic parameters were obtained by using nonlinear regression.
This process is green, clean, and easily scalable as compared to the chemical process.
American Psychological Association (APA)
Devendran, Saravanan& Yadav, Ganapati D.. 2014. Microwave Assisted Enzymatic Kinetic Resolution of (±)-1-Phenyl-2-propyn-1-ol in Nonaqueous Media. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-475120
Modern Language Association (MLA)
Devendran, Saravanan& Yadav, Ganapati D.. Microwave Assisted Enzymatic Kinetic Resolution of (±)-1-Phenyl-2-propyn-1-ol in Nonaqueous Media. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-475120
American Medical Association (AMA)
Devendran, Saravanan& Yadav, Ganapati D.. Microwave Assisted Enzymatic Kinetic Resolution of (±)-1-Phenyl-2-propyn-1-ol in Nonaqueous Media. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-475120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475120