![](/images/graphics-bg.png)
Investigation of Differences in P53 Gene Polymorphisms between Schizophrenia and Lung Cancer Patients in the Turkish Population
المؤلفون المشاركون
Özbey, Ulku
Yüce, Hüseyin
Elkiran, Tamer
Namli, Mustafa
المصدر
Genetics Research International
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
The reduced incidence of cancer observed in schizophrenia patients may be related to differences in genetic background.
It has been suggested that genetic predisposition towards schizophrenia is associated with reduced vulnerability to lung cancer, and p53 gene is one of the candidate genes.
In our study, we aimed to investigate polymorphisms in the BstUI in exon 4 and MspI in intron 6 restriction sites of the p53 gene in Turkish schizophrenia patients, lung cancer patients, and controls.
Material and Methods.
Allele and genotype incidence of these polymorphisms with their haplotype combinations were studied in 100 Turkish lung cancer and schizophrenia patients and 100 controls without malignant and schizophrenia diseases.
The genotype characteristics were determined by PCR-based RFLP method using DNA extracted from peripheral blood.
Results.
For the BstUI and MspI polymorphism, there were found significant differences in the genotype and allele frequencies between schizophrenia and lung cancer patients with control groups (P<.01).
The analysis based on haplotype frequencies showed the presence of BstUI-MspI 2-1 haplotype in cancer patients (12%) in contrast to the absence of this haplotype in schizophrenia and controls.
Only in lung cancer patients we found both significant decrease of A1 allele of the p53 codon 72 (OR 0.23, 95% CI 0.9–0.58) and A1/A1 homozygous genotype (P<.0001, OR 0.19).
Conclusion.
The results of this study suggest a protective effect of A1 allele against lung cancer, and the p53 MspI polymorphism may modify the susceptibility to lung cancer as a single factor rather than in combination with BstUI polymorphism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Özbey, Ulku& Yüce, Hüseyin& Namli, Mustafa& Elkiran, Tamer. 2011. Investigation of Differences in P53 Gene Polymorphisms between Schizophrenia and Lung Cancer Patients in the Turkish Population. Genetics Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475241
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Özbey, Ulku…[et al.]. Investigation of Differences in P53 Gene Polymorphisms between Schizophrenia and Lung Cancer Patients in the Turkish Population. Genetics Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-475241
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Özbey, Ulku& Yüce, Hüseyin& Namli, Mustafa& Elkiran, Tamer. Investigation of Differences in P53 Gene Polymorphisms between Schizophrenia and Lung Cancer Patients in the Turkish Population. Genetics Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475241
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475241
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)