Development of Novel In Silico Model to Predict Corneal Permeability for Congeneric Drugs : A QSPR Approach
المؤلفون المشاركون
Sharma, Charu
Biswas, Nihar Ranjan
Ghose, Supriyo
Velpandian, Thirumurthy
Vajpayee, Rasik Bihari
Niranjan, Nayak
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This study was undertaken to determine in vivo permeability coefficients for fluoroquinolones and to assess its correlation with the permeability derived using reported models in the literature.
Further, the aim was to develop novel QSPR model to predict corneal permeability for fluoroquinolones and test its suitability on other training sets.
The in vivo permeability coefficient was determined using cassette dosing (N-in-One) approach for nine fluoroquinolones (norfloxacin, ciprofloxacin, lomefloxacin, ofloxacin, levofloxacin, sparfloxacin, pefloxacin, gatifloxacin, and moxifloxacin) in rabbits.
The correlation between corneal permeability derived using in vivo studies with that derived from reported models was determined.
Novel QSPR-based model was developed using in vivo corneal permeability along with other molecular descriptors.
The suitability of developed model was tested on β-blockers (n=15).
The model showed better prediction of corneal permeability for fluoroquinolones (r2>0.9) as well as β-blockers (r2>0.6).
The newly developed QSPR model based upon in vivo generated data was found suitable to predict corneal permeability for fluoroquinolones as well as other sets of compounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharma, Charu& Velpandian, Thirumurthy& Biswas, Nihar Ranjan& Niranjan, Nayak& Vajpayee, Rasik Bihari& Ghose, Supriyo. 2011. Development of Novel In Silico Model to Predict Corneal Permeability for Congeneric Drugs : A QSPR Approach. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-475247
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharma, Charu…[et al.]. Development of Novel In Silico Model to Predict Corneal Permeability for Congeneric Drugs : A QSPR Approach. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-475247
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharma, Charu& Velpandian, Thirumurthy& Biswas, Nihar Ranjan& Niranjan, Nayak& Vajpayee, Rasik Bihari& Ghose, Supriyo. Development of Novel In Silico Model to Predict Corneal Permeability for Congeneric Drugs : A QSPR Approach. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-475247
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475247
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر