Efficacy of a “Rescue” Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures
المؤلفون المشاركون
Piana, Andrea
Are, Bianca
Mura, Ida
Dore, Maria Pina
Massarelli, Giovannino
Fanciulli, Giuseppe
Tadeu, Vincenza
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-14
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The aim of our study was to evaluate the efficacy and tolerability of a ciprofloxacin-based regimen for H.
pylori eradication failures as an alternative to bismuth based quadruple therapy.
Methods.
Design: prospective single-center study.
Patients in whom a first eradication trial with omeprazole/esomeprazole, clarithromycin plus amoxicillin or tinidazole/metronidazole had failed were included.
H.
pylori status: established by histology, rapide urease test and polymerase chain reaction.
Intervention: esomeprazole 20 mg, ciprofloxacin 500 mg, and metronidazole 500 mg, administered together before breakfast and dinner for 10 days.
Susceptibility testing was performed by the Epsilometer test.
Ciprofloxacin resistance was defined as a MIC of ≥1 μg/mL.
Eradication was established by a negative 13C-UBT and 4–6 weeks post-therapy.
Efficacy and side effects were determined.
Results.
34 patients were enrolled, 32 completed the study.
Compliance was excellent (100%).
Side effects were mild.
Ciprofloxacin-based therapy cured 65% (22/34) of patients by intention to treat and 69% (22/32) per protocol analysis.
The prevalence of ciprofloxacin resistance was 8%.
Conclusions.
The effectiveness of ciprofloxacin-based therapy was greatly reduced despite the high prevalence of ciprofloxacin sensitive H.
pylori strains.
Bismuth based quadruple therapy still remain the best choice as a “rescue” regimen in our region.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dore, Maria Pina& Tadeu, Vincenza& Are, Bianca& Mura, Ida& Fanciulli, Giuseppe& Massarelli, Giovannino…[et al.]. 2012. Efficacy of a “Rescue” Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-475304
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dore, Maria Pina…[et al.]. Efficacy of a “Rescue” Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures. Gastroenterology Research and Practice No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-475304
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dore, Maria Pina& Tadeu, Vincenza& Are, Bianca& Mura, Ida& Fanciulli, Giuseppe& Massarelli, Giovannino…[et al.]. Efficacy of a “Rescue” Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-475304
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475304
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر