Genetics of Myasthenia Gravis : A Case-Control Association Study in the Hellenic Population
المؤلفون المشاركون
Zagoriti, Zoi
Georgitsi, Marianthi
Ntellos, Fotios
Tzartos, Socrates J.
Patrinos, George P.
Giannakopoulou, Olga
Poulas, Konstantinos
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Myasthenia gravis (MG) is an heterogeneous autoimmune disease characterized by the production of autoantibodies against proteins of the postsynaptic membrane, in the neuromuscular junction.
The contribution of genetic factors to MG susceptibility has been evaluated through family and twin studies however, the precise genetic background of the disease remains elusive.
We conducted a case-control association study in 101 unrelated MG patients of Hellenic origin and 101 healthy volunteers in order to assess the involvement of common genetic variants in susceptibility to MG.
We focused on three candidate genes which have been clearly associated with several autoimmune diseases, aiming to investigate their potential implication in MG pathogenesis.
These are interferon regulatory factor 5 (IRF-5), TNFα-induced protein 3 (TNFAIP3), also known as A20, and interleukin-10 (IL-10), key molecules in the regulation of immune function.
A statistical trend of association (P=0.068) between IL-10 promoter single nucleotide polymorphisms (SNPs) and the subgroups of early and late-onset MG patients was revealed.
No statistically significant differences were observed in the rest of the variants examined.
As far as we are aware, this is the first worldwide attempt to address the possible association between IRF-5 and TNFAIP3 common genetic variants and the genetic basis of MG.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zagoriti, Zoi& Georgitsi, Marianthi& Giannakopoulou, Olga& Ntellos, Fotios& Tzartos, Socrates J.& Patrinos, George P.…[et al.]. 2012. Genetics of Myasthenia Gravis : A Case-Control Association Study in the Hellenic Population. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-475331
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zagoriti, Zoi…[et al.]. Genetics of Myasthenia Gravis : A Case-Control Association Study in the Hellenic Population. Clinical and Developmental Immunology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-475331
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zagoriti, Zoi& Georgitsi, Marianthi& Giannakopoulou, Olga& Ntellos, Fotios& Tzartos, Socrates J.& Patrinos, George P.…[et al.]. Genetics of Myasthenia Gravis : A Case-Control Association Study in the Hellenic Population. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-475331
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475331
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر