Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality
المؤلفون المشاركون
Cheng, Ruei-Tang
Chen, Sheng-Hsien
Lin, Mao- Tsun
Lin, Chian-Yuh
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-04-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
When the vehicle-treated, sham-operated mice underwent heat stress, the fraction survival and core temperature at +4 h of body heating were found to be 5 of 15 and 34.4∘C±0.3∘C, respectively.
Castration 2 weeks before the start of heat stress decreased the plasma levels of testosterone almost to zero, protected the mice from heat-induced death (fraction survival, 13/15) and reduced the hypothermia (core temperature, 37.3∘C).
The beneficial effects of castration in ameliorating lethality and hypothermia can be significantly reduced by testosterone replacement.
Heat-induced apoptosis, as indicated by terminal deoxynucleotidyl- transferase- mediatedαUDP-biotin nick end-labeling staining, were significantly prevented by castration.
In addition, heat-induced neuronal damage, as indicated by cell shrinkage and pyknosis of nucleus, to the hypothalamus was also castration-prevented.
Again, the beneficial effects of castration in reducing neuronal damage to the hypothalamus as well as apoptosis in multiple organs during heatstroke, were significantly reversed by testosterone replacement.
The data indicate that testosterone depletion by castration may protect mice from heatstroke-induced multiple organ damage and lethality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Chian-Yuh& Lin, Mao- Tsun& Cheng, Ruei-Tang& Chen, Sheng-Hsien. 2010. Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-475370
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Chian-Yuh…[et al.]. Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-475370
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Chian-Yuh& Lin, Mao- Tsun& Cheng, Ruei-Tang& Chen, Sheng-Hsien. Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-475370
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475370
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر