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The Role of M1 and M2 Macrophages in Prostate Cancer in relation to Extracapsular Tumor Extension and Biochemical Recurrence after Radical Prostatectomy
المؤلفون المشاركون
Giannoni, E.
Carini, M.
Chiarugi, P.
Minervini, A.
Masieri, L.
Mari, A.
Comito, G.
Lanciotti, M.
Raspollini, M. R.
Serni, S.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
The aim of our work was to investigate the causal connection between M1 and M2 macrophage phenotypes occurrence and prostate cancer, their correlation with tumor extension (ECE), and biochemical recurrence (BR).
Patient and Methods.
Clinical and pathological data were prospectively gathered from 93 patients treated with radical prostatectomy.
Correlations of commonly used variables were evaluated with uni- and multivariate analysis.
The relationship between M1 and M2 occurrence and BR was also assessed with Kaplan-Meier survival analysis.
Results.
Above all in 63.4% there was a M2 prevalence.
M1 occurred more frequently in OC disease, while M2 was more represented in ECE.
At univariate analysis biopsy and pathologic GS and M2 were statistically correlated with ECE.
Only pathologic GS and M2 confirmed to be correlated with ECE.
According to macrophage density BCR free survival curves presented a statistically significant difference.
When we stratified our population for M1 and M2,we did not find any statistical difference among curves.
At univariate analysis GS, pTNM, and positive margins resulted to be significant predictors of BCR, while M1 and M2 did not achieve the statistical significance.
At multivariate analysis, only GS and pathologic stage were independent predictors of BR.
Conclusion.
In our study patients with higher density of M count were associated with poor prognosis; M2 phenotype was significantly associated with ECE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lanciotti, M.& Masieri, L.& Raspollini, M. R.& Minervini, A.& Mari, A.& Comito, G.…[et al.]. 2014. The Role of M1 and M2 Macrophages in Prostate Cancer in relation to Extracapsular Tumor Extension and Biochemical Recurrence after Radical Prostatectomy. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lanciotti, M.…[et al.]. The Role of M1 and M2 Macrophages in Prostate Cancer in relation to Extracapsular Tumor Extension and Biochemical Recurrence after Radical Prostatectomy. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-475515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lanciotti, M.& Masieri, L.& Raspollini, M. R.& Minervini, A.& Mari, A.& Comito, G.…[et al.]. The Role of M1 and M2 Macrophages in Prostate Cancer in relation to Extracapsular Tumor Extension and Biochemical Recurrence after Radical Prostatectomy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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