Anti-Atherogenic Activity of Ethanolic Fraction of Terminalia arjuna Bark on Hypercholesterolemic Rabbits
المؤلفون المشاركون
Uthrapathi, Subasini
Rajapandian, Suja
Gnanamanickam, Victor Rajamanickam
Dubey, Govinda Prasad
Subramaniam, Saravanan
Subramaniam, Ramachandran
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Atherosclerosis which results from gradual deposition of lipids in medium and large arteries is a leading cause of mortality worldwide.
Terminalia arjuna is a herb of Combretaceae family which contains hypolipidemic compounds and flavonoids with high antioxidative properties.
This study was conducted to determine the effect of ethanolic fraction of T.
arjuna on blood lipids and atherosclerosis in rabbits fed with high fat diet (HFD).
Twenty New Zealand rabbits of either sex were randomly divided into five groups: the first two were normal diet group and HFD (21% fat) group and the remaining three groups received high cholesterol diet supplemented with standard drug (Atorvastatin 10 mg kg−1 body weight), T.
arjuna ethanolic fraction (100 and 200 mg kg−1 body weight), respectively.
The concentration of total cholesterol (TC), low density lipoprotein (LDL) cholesterol, triglycerides (TGs), very low density lipoprotein (VLDL) cholesterol and high density lipoprotein (HDL) cholesterol was determined in rabbits at the start of the experiment, at the 14th, 30th days and at the end of the study.
Anti-atherogenic index was calculated from the lipid profile of the rabbits before sacrifice.
At the end of the experimental period, the aorta was removed for assessment of atherosclerotic plaques.
Results show that T.
arjuna significantly decreases TC, LDL and TG levels and increases HDL and lessens atherosclerotic lesion in aorta (P < .05).
Hence T.
arjuna extract can effectively prevent the progress of atherosclerosis.
This is likely due to the effect of T.
arjuna on serum lipoproteins and its antioxidant and anti-inflammatory properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Subramaniam, Saravanan& Subramaniam, Ramachandran& Rajapandian, Suja& Uthrapathi, Subasini& Gnanamanickam, Victor Rajamanickam& Dubey, Govinda Prasad. 2011. Anti-Atherogenic Activity of Ethanolic Fraction of Terminalia arjuna Bark on Hypercholesterolemic Rabbits. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-475629
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Subramaniam, Saravanan…[et al.]. Anti-Atherogenic Activity of Ethanolic Fraction of Terminalia arjuna Bark on Hypercholesterolemic Rabbits. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-475629
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Subramaniam, Saravanan& Subramaniam, Ramachandran& Rajapandian, Suja& Uthrapathi, Subasini& Gnanamanickam, Victor Rajamanickam& Dubey, Govinda Prasad. Anti-Atherogenic Activity of Ethanolic Fraction of Terminalia arjuna Bark on Hypercholesterolemic Rabbits. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-475629
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475629
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر