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Hyperreflective Intraretinal Spots in Diabetics without and with Nonproliferative Diabetic Retinopathy : An In Vivo Study Using Spectral Domain OCT
المؤلفون المشاركون
Bini, Silvia
Midena, Edoardo
Pilotto, Elisabetta
Vujosevic, Stela
Midena, Giulia
Berton, Marianna
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate the presence of hyperreflective spots (HRS) in diabetic patients without clinically detectable retinopathy (no DR) or with nonproliferative mild to moderate retinopathy (DR) without macular edema, and compare the results to controls.
Methods.
36 subjects were enrolled: 12 with no DR, 12 with DR, and 12 normal subjects who served as controls.
All studied subjects underwent full ophthalmologic examination and spectral domain optical coherence tomography (SD-OCT).
SD-OCT images were analyzed to measure and localize HRS.
Each image was analyzed by two independent, masked examiners.
Results.
The number of HRS was significantly higher in both diabetics without and with retinopathy versus controls (P<0.05) and in diabetics with retinopathy versus diabetics without retinopathy (P<0.05).
The HRS were mainly located in the inner retina layers (inner limiting membrane, ganglion cell layer, and inner nuclear layer).
The intraobserver and interobserver agreement was almost perfect (κ> 0.9).
Conclusions.
SD-OCT hyperreflective spots are present in diabetic eyes even when clinical retinopathy is undetectable.
Their number increases with progressing retinopathy.
Initially, HRS are mainly located in the inner retina, where the resident microglia is present.
With progressing retinopathy, HRS reach the outer retinal layer.
HRS may represent a surrogate of microglial activation in diabetic retina.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vujosevic, Stela& Bini, Silvia& Midena, Giulia& Berton, Marianna& Pilotto, Elisabetta& Midena, Edoardo. 2013. Hyperreflective Intraretinal Spots in Diabetics without and with Nonproliferative Diabetic Retinopathy : An In Vivo Study Using Spectral Domain OCT. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-475897
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vujosevic, Stela…[et al.]. Hyperreflective Intraretinal Spots in Diabetics without and with Nonproliferative Diabetic Retinopathy : An In Vivo Study Using Spectral Domain OCT. Journal of Diabetes Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-475897
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vujosevic, Stela& Bini, Silvia& Midena, Giulia& Berton, Marianna& Pilotto, Elisabetta& Midena, Edoardo. Hyperreflective Intraretinal Spots in Diabetics without and with Nonproliferative Diabetic Retinopathy : An In Vivo Study Using Spectral Domain OCT. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-475897
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475897
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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