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Methylation and Expression of Immune and Inflammatory Genes in the Offspring of Bariatric Bypass Surgery Patients
المؤلفون المشاركون
Guénard, Frédéric
Vohl, Marie-Claude
Marceau, Picard
Kral, John G.
Tchernof, André
Cianflone, Katherine
Deshaies, Yves
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Maternal obesity, excess weight gain and overnutrition during pregnancy increase risks of obesity, type 2 diabetes mellitus, and cardiovascular disease in the offspring.
Maternal biliopancreatic diversion is an effective treatment for severe obesity and is beneficial for offspring born after maternal surgery (AMS).
These offspring exhibit lower severe obesity prevalence and improved cardiometabolic risk factors including inflammatory marker compared to siblings born before maternal surgery (BMS).
Objective.
To assess relationships between maternal bariatric surgery and the methylation/expression of genes involved in the immune and inflammatory pathways.
Methods.
A differential gene methylation analysis was conducted in a sibling cohort of 25 BMS and 25 AMS offspring from 20 mothers.
Following differential gene expression analysis (23 BMS and 23 AMS), pathway analysis was conducted.
Correlations between gene methylation/expression and circulating inflammatory markers were computed.
Results.
Five immune and inflammatory pathways with significant overrepresentation of both differential gene methylation and expression were identified.
In the IL-8 pathway, gene methylation correlated with both gene expression and plasma C-reactive protein levels.
Conclusion.
These results suggest that improvements in cardiometabolic risk markers in AMS compared to BMS offspring may be mediated through differential methylation of genes involved in immune and inflammatory pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guénard, Frédéric& Tchernof, André& Deshaies, Yves& Cianflone, Katherine& Kral, John G.& Marceau, Picard…[et al.]. 2013. Methylation and Expression of Immune and Inflammatory Genes in the Offspring of Bariatric Bypass Surgery Patients. Journal of Obesity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-475936
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guénard, Frédéric…[et al.]. Methylation and Expression of Immune and Inflammatory Genes in the Offspring of Bariatric Bypass Surgery Patients. Journal of Obesity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-475936
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guénard, Frédéric& Tchernof, André& Deshaies, Yves& Cianflone, Katherine& Kral, John G.& Marceau, Picard…[et al.]. Methylation and Expression of Immune and Inflammatory Genes in the Offspring of Bariatric Bypass Surgery Patients. Journal of Obesity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-475936
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-475936
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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