Asbestos-Induced Cellular and Molecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis

المؤلفون المشاركون

Lee, Suni
Kishimoto, Takumi
Hiratsuka, Junichi
Maeda, Megumi
Otsuki, Takemi
Yamamoto, Shoko
Tabata, Rika
Kojima, Yoko
Nishimura, Yasumitsu
Matsuzaki, Hidenori
Hatayama, Tamayo
Hayashi, Hiroaki
Kumagai-Takei, Naoko

المصدر

Journal of Biomedicine and Biotechnology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-02-06

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Asbestos causes lung fibrosis known as asbestosis as well as cancers such as malignant mesothelioma and lung cancer.

Asbestos is a mineral silicate containing iron, magnesium, and calcium with a core of SiO2.

The immunological effect of silica, SiO2, involves the dysregulation of autoimmunity because of the complications of autoimmune diseases found in silicosis.

Asbestos can therefore cause alteration of immunocompetent cells to result in a decline of tumor immunity.

Additionally, due to its physical characteristics, asbestos fibers remain in the lung, regional lymph nodes, and the pleural cavity, particularly at the opening sites of lymphatic vessels.

Asbestos can induce chronic inflammation in these areas due to the production of reactive oxygen/nitrogen species.

As a consequence, immunocompetent cells can have their cellular and molecular features altered by chronic and recurrent encounters with asbestos fibers, and there may be modification by the surrounding inflammation, all of which eventually lead to decreased tumor immunity.

In this paper, the brief results of our investigation regarding reduction of tumor immunity of immunocompetent cells exposed to asbestos in vitro are discussed, as are our findings concerned with an investigation of chronic inflammation and analyses of peripheral blood samples derived from patients with pleural plaque and mesothelioma that have been exposed to asbestos.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Matsuzaki, Hidenori& Maeda, Megumi& Lee, Suni& Nishimura, Yasumitsu& Kumagai-Takei, Naoko& Hayashi, Hiroaki…[et al.]. 2012. Asbestos-Induced Cellular and Molecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-475977

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Matsuzaki, Hidenori…[et al.]. Asbestos-Induced Cellular and Molecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-475977

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Matsuzaki, Hidenori& Maeda, Megumi& Lee, Suni& Nishimura, Yasumitsu& Kumagai-Takei, Naoko& Hayashi, Hiroaki…[et al.]. Asbestos-Induced Cellular and Molecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-475977

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-475977