Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia
المؤلفون المشاركون
Wang, Jhi-Joung
Hung, Ching-Hsia
Chen, Yu-Chung
Chen, Yu-Wen
Chang, Che-Ning
Tzeng, Jann-Inn
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study was designed to determine the severity of cardiopulmonary dysfunction during systemic endotoxemia in type 1 diabetes.
Thirty-two adult male Wistar rats were randomly assigned to a control group or to a group treated with streptozotocin (STZ) to create an animal model of type 1 diabetes.
Survival time and cardiovascular parameters were continually monitored in urethane anaesthetized animals receiving intravenous infusion of endotoxin (lipopolysaccharide (LPS)) or saline.
We also determined arterial blood gases, lung injury, and tumor necrosis factor-alpha (TNF-α) levels in serum and bronchoalveolar lavage fluid.
Before LPS administration, the mean arterial pressure in STZ rats was significantly higher than that in normal rats.
After LPS injection, the heart rate drop significantly in STZ rats than that in the control group.
Also, the increased levels of TNF-α in serum and lavage fluid after LPS treatment were significantly higher in STZ rats than those in normal rats.
Survival time in STZ rats was shorter than that in normal rats after LPS application.
Albumin content, wet/dry weight ratio of lung, and lung injury were indistinguishable between STZ and normal rats.
These results indicate that the cardiopulmonary change which occurs during LPS-induced endotoxemia is minor in STZ-induced diabetic rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hung, Ching-Hsia& Chang, Che-Ning& Chen, Yu-Wen& Chen, Yu-Chung& Tzeng, Jann-Inn& Wang, Jhi-Joung. 2013. Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-476130
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hung, Ching-Hsia…[et al.]. Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-476130
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hung, Ching-Hsia& Chang, Che-Ning& Chen, Yu-Wen& Chen, Yu-Chung& Tzeng, Jann-Inn& Wang, Jhi-Joung. Cardiopulmonary Profile in Streptozotocin-Induced Type 1 Diabetic Rats during Systemic Endotoxemia. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-476130
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476130
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر