A Changing Perspective on the Role of Neuroinflammation in Alzheimer's Disease
المؤلف
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Alzheimer's disease (AD) is a complex, neurodegenerative disorder characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain.
Glial cells, particularly microglial cells, react to the presence of the amyloid plaques and neurofibrillary tangles producing an inflammatory response.
While once considered immunologically privileged due to the blood-brain barrier, it is now understood that the glial cells of the brain are capable of complex inflammatory responses.
This paper will discuss the published literature regarding the diverse roles of neuroinflammation in the modulation of AD pathologies.
These data will then be related to the well-characterized macrophage phenotypes.
The conclusion is that the glial cells of the brain are capable of a host of macrophage responses, termed M1, M2a, M2b, and M2c.
The relationship between these states and AD pathologies remains relatively understudied, yet published data using various inflammatory stimuli provides some insight.
It appears that an M1-type response lowers amyloid load but exacerbates neurofibrillary tangle pathology.
In contrast, M2a is accompanied by elevated amyloid load and appears to ameliorate, somewhat, neurofibrillary pathology.
Overall, it is clear that more focused, cause-effect studies need to be performed to better establish how each inflammatory state can modulate the pathologies of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wilcock, Donna M.. 2012. A Changing Perspective on the Role of Neuroinflammation in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-476211
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wilcock, Donna M.. A Changing Perspective on the Role of Neuroinflammation in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-476211
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wilcock, Donna M.. A Changing Perspective on the Role of Neuroinflammation in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-476211
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476211
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر