AP-1 Gene Expression Levels May Be Correlated with Changes in Gene Expression of Some Stemness Factors in Colon Carcinomas
المؤلفون المشاركون
Papasotiriou, Ioannis
Apostolou, Panagiotis
Vlachou, Ioanna
Toloudi, Maria
Ioannou, Eleni
Kourtidou, Eleni
Chatziioannou, Marina
المصدر
Journal of Signal Transduction
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-11
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The AP-1 transcription factor is a heterodimer protein that regulates gene expression in response to a variety of extrinsic stimuli through signal transduction.
It is involved in processes including differentiation, proliferation, and apoptosis.
Among the genes it regulates are transcription factors that contribute to the stemness phenotype.
Cancer stem cells have the ability to self-renew and initiate differentiation into heterogenic cancer cells, which may cause metastasis and relapses.
In the present study, we evaluated the effect of AP-1 complexes, as well as the C-FOS and C-JUN genes, in relation to NANOG, OCT3/4, and SOX2 transcription factors.
All assays were undertaken with colon cancer stem cells.
Knockdown experiments with siRNA were performed for each individual gene as well as their combination.
Changes in gene expression were calculated with quantitative polymerase chain reaction experiments, while the effect on cell cycle distribution and apoptosis was studied by flow cytometry.
The results differed depending on the percentage of repression, as well as the gene that was suppressed.
In all cases, the number of apoptotic cells was increased.
These findings indicate that AP-1 may have a crucial role in the maintenance of cancer stem cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Apostolou, Panagiotis& Toloudi, Maria& Ioannou, Eleni& Chatziioannou, Marina& Kourtidou, Eleni& Vlachou, Ioanna…[et al.]. 2013. AP-1 Gene Expression Levels May Be Correlated with Changes in Gene Expression of Some Stemness Factors in Colon Carcinomas. Journal of Signal Transduction،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-476390
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Apostolou, Panagiotis…[et al.]. AP-1 Gene Expression Levels May Be Correlated with Changes in Gene Expression of Some Stemness Factors in Colon Carcinomas. Journal of Signal Transduction No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-476390
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Apostolou, Panagiotis& Toloudi, Maria& Ioannou, Eleni& Chatziioannou, Marina& Kourtidou, Eleni& Vlachou, Ioanna…[et al.]. AP-1 Gene Expression Levels May Be Correlated with Changes in Gene Expression of Some Stemness Factors in Colon Carcinomas. Journal of Signal Transduction. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-476390
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476390
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر