Antioxidant and Preventive Effects of Extract from Nymphaea candida Flower on In Vitro Immunological Liver Injury of Rat Primary Hepatocyte Cultures
المؤلفون المشاركون
Zhao, Jun
Gu, Zhengyi
Zhao, Yu
Ma, Long
Xu, Fang
Yan, Ming
Liu, Tao
Huang, Yi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Nymphaea candida is traditional Uighur medicine that is commonly used to treat head pains, cough, hepatitis and hypertension in Xinjiang of China.
In this article, the extract of N.
candida was measured for antioxidant activity, using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals scavenging assay and reducing power determination, and compared with those of the positive controls of butylated hydroxytoluene (BHT) and gallic acid (GA).
The active extract was further purified by liquid-liquid partition to afford four fractions, of which the ethyl acetate-soluble (EA) fraction (NCE) exhibited the strongest antioxidant capacity with IC50 value of 12.6 μg/mL for DPPH.
Thirteen phenolic compounds were isolated from this fraction, and they all showed significant antioxidant activities in DPPH model system.
Furthermore, NCE showed potent antioxidant capacity with IC50 value of 59.32 μg/mL, 24.48 μg/mL and 86.85 μg/mL, for O2−, ·OH and H2O2 radicals, respectively.
Moreover, NCE on BCG plus LPS-induced immunological liver injury was evaluated using primary cultured rat hepatocytes.
NCE produced significant hepatoprotective effects as evidenced by decreased supernatant enzyme activities (AST—aspartate transaminase, P < .01; ALT—alanine transferase, P < .01) and nitric oxide (NO, P < .01) production.
These results revealed the in vitro antioxidant and hepatoprotective activities of NCE against immunological liver injury.
Further investigations are necessary to verify these activities in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Jun& Liu, Tao& Ma, Long& Yan, Ming& Gu, Zhengyi& Huang, Yi…[et al.]. 2011. Antioxidant and Preventive Effects of Extract from Nymphaea candida Flower on In Vitro Immunological Liver Injury of Rat Primary Hepatocyte Cultures. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-476422
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Jun…[et al.]. Antioxidant and Preventive Effects of Extract from Nymphaea candida Flower on In Vitro Immunological Liver Injury of Rat Primary Hepatocyte Cultures. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-476422
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Jun& Liu, Tao& Ma, Long& Yan, Ming& Gu, Zhengyi& Huang, Yi…[et al.]. Antioxidant and Preventive Effects of Extract from Nymphaea candida Flower on In Vitro Immunological Liver Injury of Rat Primary Hepatocyte Cultures. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-476422
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476422
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر