An Angiotensin I Converting Enzyme Polymorphism Is Associated with Clinical Phenotype When Using Differentiation-Syndrome to Categorize Korean Bronchial Asthma Patients
المؤلفون المشاركون
Seo, Jungchul
Hong, Mee-Suk
Cho, Yong-Ju
Chung, Joo-Ho
Choi, Jun-Yong
Jung, Hee-Jae
Jung, Sung-ki
Ra, Jehyeon
Kim, Jinju
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
In this study, genetic analysis was conducted to investigate the association of angiotensin I converting enzyme (ACE) gene polymorphism with clinical phenotype based on differentiation-syndrome of bronchial asthma patients.
Differentiation-syndrome is a traditional Korean medicine (TKM) theory in which patients are classified into a Deficiency Syndrome Group (DSG) and an Excess Syndrome Group (ESG) according to their symptomatic classification.
For this study, 110 participants were evaluated by pulmonary function test.
Among them, 39 patients were excluded because they refused genotyping.
Of the remaining patients, 52 with DSG of asthma (DSGA) and 29 with ESG of asthma (ESGA), as determined by the differentiation-syndrome techniques were assessed by genetic analysis.
ACE insertion/deletion (I/D) polymorphism analysis was conducted using polymerase chain reaction (PCR).
Student's t, chi-square, Fisher and Hardy-Weinberg equilibrium tests were used to compare groups.
No significant differences in pulmonary function were observed between DSGA and ESGA.
The genotypic frequency of ACE I/D polymorphism was found to differ slightly between DSGA and ESGA (P = .0495).
However, there were no significant differences in allelic frequency observed between DSGA and ESGA (P = .7006, OR = 1.1223).
Interestingly, the allelic (P = .0043, OR = 3.4545) and genotypic (P = .0126) frequencies of the ACE I/D polymorphism in female patients differed significantly between DSGA and ESGA.
Taken together, the results presented here indicate that the symptomatic classification of DSGA and ESGA by differentiation-syndrome in Korean asthma patients could be useful in evaluation of the pathogenesis of bronchial asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jung, Sung-ki& Ra, Jehyeon& Seo, Jungchul& Jung, Hee-Jae& Choi, Jun-Yong& Cho, Yong-Ju…[et al.]. 2011. An Angiotensin I Converting Enzyme Polymorphism Is Associated with Clinical Phenotype When Using Differentiation-Syndrome to Categorize Korean Bronchial Asthma Patients. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-476466
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jung, Sung-ki…[et al.]. An Angiotensin I Converting Enzyme Polymorphism Is Associated with Clinical Phenotype When Using Differentiation-Syndrome to Categorize Korean Bronchial Asthma Patients. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-476466
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jung, Sung-ki& Ra, Jehyeon& Seo, Jungchul& Jung, Hee-Jae& Choi, Jun-Yong& Cho, Yong-Ju…[et al.]. An Angiotensin I Converting Enzyme Polymorphism Is Associated with Clinical Phenotype When Using Differentiation-Syndrome to Categorize Korean Bronchial Asthma Patients. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-476466
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476466
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر