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Glomerulopathy in the KK.Cg-AyJ Mouse Reflects the Pathology of Diabetic Nephropathy
المؤلفون المشاركون
Arbeeny, Cynthia
Wawersik, Stefan
Lydon, John
Ledbetter, Steven
Smith, Mandy
Phillips, Lucy
Ling, Hong
Maloney, Colleen
O'Brien, Stephen P.
Weber, William
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-24
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The KK.Cg-Ay/J (KK-Ay) mouse strain is a previously described model of type 2 diabetes with renal impairment.
In the present study, female KK-Ay mice received an elevated fat content diet (24% of calories), and a cohort was uninephrectomized (Unx) to drive renal disease severity.
Compared to KK-a/a controls, 26-week-old KK-Ay mice had elevated HbA1c, insulin, leptin, triglycerides, and cholesterol, and Unx further elevated these markers of metabolic dysregulation.
Unx KK-Ay mice also exhibited elevated serum BUN and reduced glomerular filtration, indicating that reduction in renal mass leads to more severe impairment in renal function.
Glomerular hypertrophy and hypercellularity, mesangial matrix expansion, podocyte effacement, and basement membrane thickening were present in both binephric and uninephrectomized cohorts.
Glomerular size was increased in both groups, but podocyte density was reduced only in the Unx animals.
Consistent with functional and histological evidence of increased injury, fibrotic (fibronectin 1, MMP9, and TGFβ1) and inflammatory (IL-6, CD68) genes were markedly upregulated in Unx KK-Ay mice, while podocyte markers (nephrin and podocin) were significantly decreased.
These data suggest podocyte injury developing into glomerulopathy in KK-Ay mice.
The addition of uninephrectomy enhances renal injury in this model, resulting in a disease which more closely resembles human diabetic nephropathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
O'Brien, Stephen P.& Smith, Mandy& Ling, Hong& Phillips, Lucy& Weber, William& Lydon, John…[et al.]. 2013. Glomerulopathy in the KK.Cg-AyJ Mouse Reflects the Pathology of Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-476540
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
O'Brien, Stephen P.…[et al.]. Glomerulopathy in the KK.Cg-AyJ Mouse Reflects the Pathology of Diabetic Nephropathy. Journal of Diabetes Research No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-476540
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
O'Brien, Stephen P.& Smith, Mandy& Ling, Hong& Phillips, Lucy& Weber, William& Lydon, John…[et al.]. Glomerulopathy in the KK.Cg-AyJ Mouse Reflects the Pathology of Diabetic Nephropathy. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-476540
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476540
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