Ankylosing Spondylitis : From Cells to Genes
المؤلفون المشاركون
Zambrano-Zaragoza, José Francisco
Vibanco-Pérez, Norberto
Agraz-Cibrian, Juan Manuel
Durán-Avelar, Ma. de Jesús
González-Reyes, Christian
المصدر
International Journal of Inflammation
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-21
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown etiology, though it is considered an autoimmune disease.
HLA-B27 is the risk factor most often associated with AS, and although the mechanism of involvement is unclear, the subtypes and other features of the relationship between HLA-B27 and AS have been studied for years.
Additionally, the key role of IL-17 and Th17 cells in autoimmunity and inflammation suggests that the latter and the cytokines involved in their generation could play a role in the pathogenesis of this disease.
Recent studies have described the sources of IL-17 and IL-23, as well as the characterization of Th17 cells in autoimmune diseases.
Other cells, such as NK and regulatory T cells, have been implicated in autoimmunity and have been evaluated to ascertain their possible role in AS.
Moreover, several polymorphisms, mutations and deletions in the regulatory proteins, protein-coding regions, and promoter regions of different genes involved in immune responses have been discovered and evaluated for possible genetic linkages to AS.
In this review, we analyze the features of HLA-B27 and the suggested mechanisms of its involvement in AS while also focusing on the characterization of the immune response and the identification of genes associated with AS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zambrano-Zaragoza, José Francisco& Agraz-Cibrian, Juan Manuel& González-Reyes, Christian& Durán-Avelar, Ma. de Jesús& Vibanco-Pérez, Norberto. 2013. Ankylosing Spondylitis : From Cells to Genes. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-476599
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zambrano-Zaragoza, José Francisco…[et al.]. Ankylosing Spondylitis : From Cells to Genes. International Journal of Inflammation No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-476599
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zambrano-Zaragoza, José Francisco& Agraz-Cibrian, Juan Manuel& González-Reyes, Christian& Durán-Avelar, Ma. de Jesús& Vibanco-Pérez, Norberto. Ankylosing Spondylitis : From Cells to Genes. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-476599
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476599
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر