Cytomegalovirus in the Neonate : Immune Correlates of Infection and Protection
المؤلف
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Fetal and neonatal infections caused by human cytomegalovirus (CMV) are important causes of morbidity and occasional mortality.
Development of a vaccine against congenital CMV infection is a major public health priority.
Vaccine design is currently focused on strategies that aim to elicit neutralizing antibody and T-cell responses, toward the goal of preventing primary or recurrent infection in women of child-bearing age.
However, there has been relatively little attention given to understanding the mechanisms of immune protection against acquisition of CMV infection in the fetus and newborn and how this information might be exploited for vaccine design.
There has similarly been an insufficient study of what deficits in the immune response to CMV, both for mother and fetus, may increase susceptibility to congenital infection and disease.
Protection of the fetus against vertical transmission can likely be achieved by protection of the placenta, which has its own unique immunological milieu, further complicating the analysis of the correlates of protective immunity.
In this review, the current state of knowledge about immune effectors of protection against CMV in the maternal, placental, and fetal compartments is reviewed.
A better understanding of immune responses that prevent and/or predispose to infection will help in the development of novel vaccine strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schleiss, Mark R.. 2013. Cytomegalovirus in the Neonate : Immune Correlates of Infection and Protection. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-476620
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schleiss, Mark R.. Cytomegalovirus in the Neonate : Immune Correlates of Infection and Protection. Clinical and Developmental Immunology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-476620
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schleiss, Mark R.. Cytomegalovirus in the Neonate : Immune Correlates of Infection and Protection. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-476620
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476620
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر