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Alzheimer's Disease : APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System
المؤلف
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-34، 34ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-29
دولة النشر
مصر
عدد الصفحات
34
التخصصات الرئيسية
الملخص EN
Alzheimer's disease susceptibility genes, APP and gamma-secretase, are involved in the herpes simplex life cycle, and that of other suspect pathogens (C.
pneumoniae, H.
pylori, C.
neoformans, B.
burgdorferri, P.
gingivalis) or immune defence.
Such pathogens promote beta-amyloid deposition and tau phosphorylation and may thus be causative agents, whose effects are conditioned by genes.
The antimicrobial effects of beta-amyloid, the localisation of APP/gamma-secretase in immunocompetent dendritic cells, and gamma secretase cleavage of numerous pathogen receptors suggest that this network is concerned with pathogen disposal, effects which may be abrogated by the presence of beta-amyloid autoantibodies in the elderly.
These autoantibodies, as well as those to nerve growth factor and tau, also observed in Alzheimer's disease, may well be antibodies to pathogens, due to homology between human autoantigens and pathogen proteins.
NGF or tau antibodies promote beta-amyloid deposition, neurofibrillary tangles, or cholinergic neuronal loss, and, with other autoantibodies, such as anti-ATPase, are potential agents of destruction, whose formation is dictated by sequence homology between pathogen and human proteins, and thus by pathogen strain and human genes.
Pathogen elimination in the ageing population and removal of culpable autoantibodies might reduce the incidence and offer hope for a cure in this affliction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carter, Chris. 2011. Alzheimer's Disease : APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-34.
https://search.emarefa.net/detail/BIM-476630
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carter, Chris. Alzheimer's Disease : APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-34.
https://search.emarefa.net/detail/BIM-476630
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carter, Chris. Alzheimer's Disease : APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-34.
https://search.emarefa.net/detail/BIM-476630
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476630
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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