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Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells
المؤلفون المشاركون
Yun, Jeong Won
Choi, Yung Hyun
Kim, Dong Chul
Lee, Won-Sup
Ryu, Chung Ho
Jeong, Jae-Hoon
Kim, Gon-Sup
Lu, Jing Nan
Kim, Hye Jung
Shin, Sung Chul
Kim, Min Jeong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Recently we have demonstrated that anthocyanins from fruits of Vitis coignetiae Pulliat (AIMs) have anticancer effects.
Here, we investigate the effects of AIMs on cell proliferation and invasion as well as epithelial-mesenchymal transition (EMT) which have been linked to cancer metastasis in human uterine cervical cancer HeLa cells.
AIMs inhibited the invasion of HeLa cells in a dose-dependent manner.
AIMs inhibited MMP-9 expression in a dose-dependent manner.
AIMs inhibited the motility of HeLa cells in a wound healing test.
AIMs still suppressed NF-κB activation induced by TNF.
AIMs also inhibited EMT in HeLa cells.
AIMs suppressed vimentin, N-cadherin, and β-catenin expression and induced E-cadherin.
AIMs also suppressed expression of β-catenin and Snail, which was regulated by GSK-3.
These effects of AIMs were also limited in the HeLa cells treated with TNF.
In conclusion, this study indicates that AIMs have anticancer effects by suppressing NF-κB-regulated genes and EMT, which relates to suppression of IκBα phosphorylation and GSK-3 activity, respectively.
However, the effects of AIMs were attenuated in the TNF-high condition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Jing Nan& Lee, Won-Sup& Yun, Jeong Won& Kim, Min Jeong& Kim, Hye Jung& Kim, Dong Chul…[et al.]. 2013. Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-476756
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Jing Nan…[et al.]. Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-476756
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Jing Nan& Lee, Won-Sup& Yun, Jeong Won& Kim, Min Jeong& Kim, Hye Jung& Kim, Dong Chul…[et al.]. Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-476756
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476756
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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