Churg-Strauss Syndrome following PTU Treatment

الملخص EN

Propylthiouracil (PTU) is a frequently prescribed drug in the treatment of hyperthyroidism.

The use of PTU is, however, accompanied by numerous potentially serious side effects including vasculitis.

PTU-related vasculitides can present as haematuria, pulmonary haemorrhage, or cutaneous lesion together with aspecific symptoms such as fever, myalgia, arthralgia, and fatigue.

Cerebral involvement is seldom observed.

We present a 49-year-old female with Graves' disease and asthma, who developed paresis of the proximal extremities, eosinophilia, pulmonary, and cutaneous lesions following treatment with PTU.

A cerebral vasculitis consistent with Churg-Strauss syndrome (CSS) was suspected.

Although cerebral involvement is seldom observed with PTU treatment, cerebral vasculitis should be considered in patients developing CNS symptoms.