Microwave-Assisted Synthesis of Isopropyl β-(3,4-Dihydroxyphenyl)‎-α-hydroxypropanoate

المؤلفون المشاركون

Wang, Yi
Tian, Xue-Feng
Zhang, Xun-Li
Pan, Qing
Zhang, Qun-Zheng
Du, Guan-Le

المصدر

Journal of Chemistry

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-09-08

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الكيمياء

الملخص EN

Using microwave irradiation heating, isopropyl β-(3,4-dihydroxyphenyl)-α-hydroxypropanoate was synthesised from 3,4-dihydroxybenzaldehyde and acetylglycine through the formation of 2-methyl-4-(3,4-acetoxybenzylene)oxazol-5-ones, α-acetylamino-β-(3,4-diacetoxyphenyl)acrylic acid, and β-(3,4-dihydroxyphenyl)pyruvic acid followed by Clemmensen reduction and esterification.

The reaction conditions in terms of operating parameters were optimised by using an orthogonal design of experiment (ODOE) approach, including reaction temperature, reaction time, and microwave power level.

Compared with conventional heating, the reaction time was significantly reduced for all reactions and the product yields were increased (except for the third-step reaction) under microwave heating conditions.

The most remarkable microwave enhancement was found in the step of isopropyl β-(3,4-dihydroxyphenyl)-α-hydroxypropanoate production where the reaction time was reduced from 10 hrs (conventional heating) to 25 mins (microwave heating) whilst the yield was increased from 75.6% to 87.1%, respectively.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Qun-Zheng& Tian, Xue-Feng& Du, Guan-Le& Pan, Qing& Wang, Yi& Zhang, Xun-Li. 2013. Microwave-Assisted Synthesis of Isopropyl β-(3,4-Dihydroxyphenyl)-α-hydroxypropanoate. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476971

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Qun-Zheng…[et al.]. Microwave-Assisted Synthesis of Isopropyl β-(3,4-Dihydroxyphenyl)-α-hydroxypropanoate. Journal of Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-476971

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Qun-Zheng& Tian, Xue-Feng& Du, Guan-Le& Pan, Qing& Wang, Yi& Zhang, Xun-Li. Microwave-Assisted Synthesis of Isopropyl β-(3,4-Dihydroxyphenyl)-α-hydroxypropanoate. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476971

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-476971