Microwave-Assisted Synthesis of Isopropyl β-(3,4-Dihydroxyphenyl)-α-hydroxypropanoate
Joint Authors
Wang, Yi
Tian, Xue-Feng
Zhang, Xun-Li
Pan, Qing
Zhang, Qun-Zheng
Du, Guan-Le
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Using microwave irradiation heating, isopropyl β-(3,4-dihydroxyphenyl)-α-hydroxypropanoate was synthesised from 3,4-dihydroxybenzaldehyde and acetylglycine through the formation of 2-methyl-4-(3,4-acetoxybenzylene)oxazol-5-ones, α-acetylamino-β-(3,4-diacetoxyphenyl)acrylic acid, and β-(3,4-dihydroxyphenyl)pyruvic acid followed by Clemmensen reduction and esterification.
The reaction conditions in terms of operating parameters were optimised by using an orthogonal design of experiment (ODOE) approach, including reaction temperature, reaction time, and microwave power level.
Compared with conventional heating, the reaction time was significantly reduced for all reactions and the product yields were increased (except for the third-step reaction) under microwave heating conditions.
The most remarkable microwave enhancement was found in the step of isopropyl β-(3,4-dihydroxyphenyl)-α-hydroxypropanoate production where the reaction time was reduced from 10 hrs (conventional heating) to 25 mins (microwave heating) whilst the yield was increased from 75.6% to 87.1%, respectively.
American Psychological Association (APA)
Zhang, Qun-Zheng& Tian, Xue-Feng& Du, Guan-Le& Pan, Qing& Wang, Yi& Zhang, Xun-Li. 2013. Microwave-Assisted Synthesis of Isopropyl β-(3,4-Dihydroxyphenyl)-α-hydroxypropanoate. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476971
Modern Language Association (MLA)
Zhang, Qun-Zheng…[et al.]. Microwave-Assisted Synthesis of Isopropyl β-(3,4-Dihydroxyphenyl)-α-hydroxypropanoate. Journal of Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-476971
American Medical Association (AMA)
Zhang, Qun-Zheng& Tian, Xue-Feng& Du, Guan-Le& Pan, Qing& Wang, Yi& Zhang, Xun-Li. Microwave-Assisted Synthesis of Isopropyl β-(3,4-Dihydroxyphenyl)-α-hydroxypropanoate. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476971
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476971